发育期镉暴露对健康和疾病的影响。

IF 3.3 3区 医学 Q2 CELL BIOLOGY
Disease Models & Mechanisms Pub Date : 2025-06-01 Epub Date: 2025-06-09 DOI:10.1242/dmm.052038
Kathleen M Hudson, Logan Dameris, Rebecca Lichtler, Michael Cowley
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引用次数: 0

摘要

镉(Cd)是一种天然存在的有毒重金属,在整个环境中无处不在。自工业化开始以来,人为活动导致了广泛的环境污染,大大增加了人类接触和相关的健康风险。作为世界卫生组织引起重大公共卫生关注的十大化学品之一,Cd对人类健康构成重大风险,特别是在发育的关键阶段接触时。Cd在胎盘中积累,可在脐带血、胎儿和新生儿组织中检测到,因此了解生命早期Cd暴露的后果及其潜在的分子机制至关重要。在这篇综述中,我们概述了目前用于研究发育期镉暴露的模型,并整合了流行病学、动物和体外研究的结果。我们探讨了生命早期Cd暴露对胎盘、生长发育和器官系统的影响和机制,确定了不同模型系统的共同主题。最后,我们指出了知识差距,并提出了关键的研究重点,这将促进我们的理解,并为减少Cd暴露的发展风险提供缓解策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The effects of developmental cadmium exposure on health and disease.

The effects of developmental cadmium exposure on health and disease.

The effects of developmental cadmium exposure on health and disease.

Cadmium (Cd) is a naturally occurring toxic heavy metal found ubiquitously throughout the environment. Anthropogenic activities since the onset of industrialization have led to widespread environmental contamination that has substantially increased human exposure and associated health risks. As one of the top ten chemicals of major public health concern of the World Health Organization, Cd poses significant risks to human health, particularly when exposure occurs during the critical stages of development. Cd accumulates in the placenta and can be detected in cord blood and fetal and neonatal tissues, so it is crucial to understand the consequences of early-life Cd exposure and the underlying molecular mechanisms. In this Review, we provide an overview of the models currently used to study developmental Cd exposure and integrate the findings from epidemiological, animal and in vitro studies. We explore the impacts and mechanisms of early-life Cd exposure on the placenta, growth and development, and organ systems, identifying common themes across diverse model systems. Finally, we pinpoint knowledge gaps and propose key research priorities that will advance our understanding and inform mitigation strategies for reducing the developmental risks of Cd exposure.

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来源期刊
Disease Models & Mechanisms
Disease Models & Mechanisms 医学-病理学
CiteScore
6.60
自引率
7.00%
发文量
203
审稿时长
6-12 weeks
期刊介绍: Disease Models & Mechanisms (DMM) is an online Open Access journal focusing on the use of model systems to better understand, diagnose and treat human disease.
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