游离水校正的正常白质分数各向异性作为脑血管疾病患者注意和执行功能障碍的潜在神经成像生物标志物

IF 5 1区 医学 Q1 NEUROSCIENCES
Qingyang Fu, Yage Qiu, Ying Hu, Yuanzheng Wang, Yao Wang, Wentao Hu, Qun Xu, Yawen Sun, Yan Zhou
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引用次数: 0

摘要

目的探讨脑小血管疾病(CSVD)患者脑白质完整性改变与注意/执行功能的关系,重点研究脑小血管病变分期特异性改变和识别影响认知能力下降的关键神经影像学标志物。方法对170例CSVD患者进行MRI和神经心理评估,其中血管性认知障碍(VaMCI)患者103例,无认知障碍患者67例。神经影像学指标包括白质高信号(WMH)和正常白质(NAWM)的定量敏感性(QS)、游离水(FW)、经FW校正的分数各向异性(FAt)和经FW校正的平均扩散率(MDt)。WMH体积、灰质/白质体积、腔隙性梗死(LI)体积和计数也包括在内。采用部分相关性来评估神经成像-认知关系,并采用随机森林分析来确定这些指标的相对重要性,特别关注白质束。结果VaMCI组与NCI组相比,NAWM脂肪和白质体积减少,NAWM QS、WMH体积、LI体积和计数增加。NAWM/WMH FAt与注意/执行功能呈正相关,而NAWM/WMH QS、FW、MDt、WMH体积和LI指标呈负相关。值得注意的是,NAWM脂肪是最显著的变量,特别是在额叶白质束和丘脑辐射中。结论NAWM脂肪显著影响CSVD患者的注意/执行功能,尤其是额叶和丘脑辐射,可能是认知能力下降的早期潜在神经影像学生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Free Water-Corrected Fractional Anisotropy in Normal-Appearing White Matter as a Potential Neuroimaging Biomarker for Attention and Executive Function Impairment in Cerebral Small Vessel Disease

Free Water-Corrected Fractional Anisotropy in Normal-Appearing White Matter as a Potential Neuroimaging Biomarker for Attention and Executive Function Impairment in Cerebral Small Vessel Disease

Objective

To investigate the relationship between white matter integrity changes and attention/executive function in cerebral small vessel disease (CSVD), focusing on tract-specific alterations over stages and identifying key neuroimaging markers affecting cognitive decline.

Methods

A total of 170 CSVD patients, including 103 Vascular Cognitive Impairment (VaMCI) and 67 with no cognitive impairment (NCI) underwent MRI and neuropsychological assessments. Neuroimaging metrics included quantitative susceptibility (QS), free water (FW), FW-corrected fractional anisotropy (FAt) and FW-corrected mean diffusivity (MDt) in white matter hyperintensities (WMH) and normal-appearing white matter (NAWM). WMH volume, gray/white matter volume, lacunar infarcts (LI) volume and counts were also included. Partial correlations were conducted to assess neuroimaging-cognition relationships, and random forest analysis was employed to determine the relative importance of these indices, with a particular focus on white matter tracts.

Results

The VaMCI group exhibited decreased NAWM FAt and white matter volume, increased NAWM QS, WMH volume, LI volume and counts when compared to the NCI group. NAWM/WMH FAt positively associated with attention/executive function, whereas NAWM/WMH QS, FW, MDt, WMH volume, and LI metrics negatively correlated. Notably, NAWM FAt was the most significant variable, especially in frontal white matter tracts and thalamic radiation.

Conclusion

NAWM FAt significantly impacts attention/executive function in CSVD, particularly in the frontal lobe and thalamic radiation, and may serve as an early potential neuroimaging biomarker for cognitive decline.

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来源期刊
CNS Neuroscience & Therapeutics
CNS Neuroscience & Therapeutics 医学-神经科学
CiteScore
7.30
自引率
12.70%
发文量
240
审稿时长
2 months
期刊介绍: CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.
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