Qingyang Fu, Yage Qiu, Ying Hu, Yuanzheng Wang, Yao Wang, Wentao Hu, Qun Xu, Yawen Sun, Yan Zhou
{"title":"游离水校正的正常白质分数各向异性作为脑血管疾病患者注意和执行功能障碍的潜在神经成像生物标志物","authors":"Qingyang Fu, Yage Qiu, Ying Hu, Yuanzheng Wang, Yao Wang, Wentao Hu, Qun Xu, Yawen Sun, Yan Zhou","doi":"10.1111/cns.70475","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>To investigate the relationship between white matter integrity changes and attention/executive function in cerebral small vessel disease (CSVD), focusing on tract-specific alterations over stages and identifying key neuroimaging markers affecting cognitive decline.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A total of 170 CSVD patients, including 103 Vascular Cognitive Impairment (VaMCI) and 67 with no cognitive impairment (NCI) underwent MRI and neuropsychological assessments. Neuroimaging metrics included quantitative susceptibility (QS), free water (FW), FW-corrected fractional anisotropy (FAt) and FW-corrected mean diffusivity (MDt) in white matter hyperintensities (WMH) and normal-appearing white matter (NAWM). WMH volume, gray/white matter volume, lacunar infarcts (LI) volume and counts were also included. Partial correlations were conducted to assess neuroimaging-cognition relationships, and random forest analysis was employed to determine the relative importance of these indices, with a particular focus on white matter tracts.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The VaMCI group exhibited decreased NAWM FAt and white matter volume, increased NAWM QS, WMH volume, LI volume and counts when compared to the NCI group. NAWM/WMH FAt positively associated with attention/executive function, whereas NAWM/WMH QS, FW, MDt, WMH volume, and LI metrics negatively correlated. Notably, NAWM FAt was the most significant variable, especially in frontal white matter tracts and thalamic radiation.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>NAWM FAt significantly impacts attention/executive function in CSVD, particularly in the frontal lobe and thalamic radiation, and may serve as an early potential neuroimaging biomarker for cognitive decline.</p>\n </section>\n </div>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 6","pages":""},"PeriodicalIF":5.0000,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70475","citationCount":"0","resultStr":"{\"title\":\"Free Water-Corrected Fractional Anisotropy in Normal-Appearing White Matter as a Potential Neuroimaging Biomarker for Attention and Executive Function Impairment in Cerebral Small Vessel Disease\",\"authors\":\"Qingyang Fu, Yage Qiu, Ying Hu, Yuanzheng Wang, Yao Wang, Wentao Hu, Qun Xu, Yawen Sun, Yan Zhou\",\"doi\":\"10.1111/cns.70475\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>To investigate the relationship between white matter integrity changes and attention/executive function in cerebral small vessel disease (CSVD), focusing on tract-specific alterations over stages and identifying key neuroimaging markers affecting cognitive decline.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A total of 170 CSVD patients, including 103 Vascular Cognitive Impairment (VaMCI) and 67 with no cognitive impairment (NCI) underwent MRI and neuropsychological assessments. Neuroimaging metrics included quantitative susceptibility (QS), free water (FW), FW-corrected fractional anisotropy (FAt) and FW-corrected mean diffusivity (MDt) in white matter hyperintensities (WMH) and normal-appearing white matter (NAWM). WMH volume, gray/white matter volume, lacunar infarcts (LI) volume and counts were also included. Partial correlations were conducted to assess neuroimaging-cognition relationships, and random forest analysis was employed to determine the relative importance of these indices, with a particular focus on white matter tracts.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The VaMCI group exhibited decreased NAWM FAt and white matter volume, increased NAWM QS, WMH volume, LI volume and counts when compared to the NCI group. NAWM/WMH FAt positively associated with attention/executive function, whereas NAWM/WMH QS, FW, MDt, WMH volume, and LI metrics negatively correlated. Notably, NAWM FAt was the most significant variable, especially in frontal white matter tracts and thalamic radiation.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>NAWM FAt significantly impacts attention/executive function in CSVD, particularly in the frontal lobe and thalamic radiation, and may serve as an early potential neuroimaging biomarker for cognitive decline.</p>\\n </section>\\n </div>\",\"PeriodicalId\":154,\"journal\":{\"name\":\"CNS Neuroscience & Therapeutics\",\"volume\":\"31 6\",\"pages\":\"\"},\"PeriodicalIF\":5.0000,\"publicationDate\":\"2025-06-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70475\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"CNS Neuroscience & Therapeutics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/cns.70475\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"CNS Neuroscience & Therapeutics","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/cns.70475","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Free Water-Corrected Fractional Anisotropy in Normal-Appearing White Matter as a Potential Neuroimaging Biomarker for Attention and Executive Function Impairment in Cerebral Small Vessel Disease
Objective
To investigate the relationship between white matter integrity changes and attention/executive function in cerebral small vessel disease (CSVD), focusing on tract-specific alterations over stages and identifying key neuroimaging markers affecting cognitive decline.
Methods
A total of 170 CSVD patients, including 103 Vascular Cognitive Impairment (VaMCI) and 67 with no cognitive impairment (NCI) underwent MRI and neuropsychological assessments. Neuroimaging metrics included quantitative susceptibility (QS), free water (FW), FW-corrected fractional anisotropy (FAt) and FW-corrected mean diffusivity (MDt) in white matter hyperintensities (WMH) and normal-appearing white matter (NAWM). WMH volume, gray/white matter volume, lacunar infarcts (LI) volume and counts were also included. Partial correlations were conducted to assess neuroimaging-cognition relationships, and random forest analysis was employed to determine the relative importance of these indices, with a particular focus on white matter tracts.
Results
The VaMCI group exhibited decreased NAWM FAt and white matter volume, increased NAWM QS, WMH volume, LI volume and counts when compared to the NCI group. NAWM/WMH FAt positively associated with attention/executive function, whereas NAWM/WMH QS, FW, MDt, WMH volume, and LI metrics negatively correlated. Notably, NAWM FAt was the most significant variable, especially in frontal white matter tracts and thalamic radiation.
Conclusion
NAWM FAt significantly impacts attention/executive function in CSVD, particularly in the frontal lobe and thalamic radiation, and may serve as an early potential neuroimaging biomarker for cognitive decline.
期刊介绍:
CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.