Irene Kasindi Meki, Adeyinka Jeremy Adedeji, Lalidia Bruno Ouoba, Yao Mathurin Koffi, Adama Diakité, Tirumala B. K. Settypalli, Lamouni Habibata-Zerbo, Kouamé Valère Kouakou, Mohamed Adama Diakité, Charles Masembe, Moctar Sidi, Thierry Ouattara Douyeri, Fatoumata Dembelé, Helen E. Luka, Sandaogo Hamidou-Ouandaogo, Christiane Dembelé, Rebecca Weka, Gregorie Bazimo, Martin Dakouo, Toyin A. Olubade, Mariétou Guitti-Kindo, Chaka Traoré, Olushola Gamra, Dominique Guigma, Cheick Abou Kounta Sidibé, Dupe A. Hambolu, Drabo Dji-tombo Adama, Boubacar Madio dit Aladiogo Maïga, Mary A. Ogunleye, Ayokanmi Toluhi, Nanven Maurice, Emmanuel Couacy-Hymann, Pam D. Luka, Giovanni Cattoli, Charles E. Lamien
{"title":"非洲猪瘟病毒基因II型在西非（2020）的检测及其与地方性基因I型的共循环：对生猪生产的影响","authors":"Irene Kasindi Meki, Adeyinka Jeremy Adedeji, Lalidia Bruno Ouoba, Yao Mathurin Koffi, Adama Diakité, Tirumala B. K. Settypalli, Lamouni Habibata-Zerbo, Kouamé Valère Kouakou, Mohamed Adama Diakité, Charles Masembe, Moctar Sidi, Thierry Ouattara Douyeri, Fatoumata Dembelé, Helen E. Luka, Sandaogo Hamidou-Ouandaogo, Christiane Dembelé, Rebecca Weka, Gregorie Bazimo, Martin Dakouo, Toyin A. Olubade, Mariétou Guitti-Kindo, Chaka Traoré, Olushola Gamra, Dominique Guigma, Cheick Abou Kounta Sidibé, Dupe A. Hambolu, Drabo Dji-tombo Adama, Boubacar Madio dit Aladiogo Maïga, Mary A. Ogunleye, Ayokanmi Toluhi, Nanven Maurice, Emmanuel Couacy-Hymann, Pam D. Luka, Giovanni Cattoli, Charles E. Lamien","doi":"10.1155/tbed/5396227","DOIUrl":null,"url":null,"abstract":"<div>\n <p>African swine fever (ASF) is a highly devastating disease of domestic pigs caused by the ASF virus (ASFV). Historically, only ASFV Genotype I was known to circulate in West Africa. However, Genotype II has recently emerged in Nigeria, Ghana, and Benin for the first time. Between 2017 and 2023, suspected ASF outbreaks were reported in Burkina Faso, Côte d’Ivoire, Nigeria, and Mali. The source, extent, and spread of these ASF outbreaks remain unknown. Samples collected from 2017 to 2023 were analyzed using real-time qPCR and characterized using five ASFV gene segments: partial gene of the B464L (p72), full length E183L (p54), central variable region (CVR) within B602L, EP402R (CD2v), and intergenic region (IGR) between I73R and I329L genes. ASF was confirmed in 12 Nigerian states and in seven, eight, and two provinces of Burkina Faso, Côte d’Ivoire, and Mali, respectively. Phylogenetic analysis of B646L (p72), E183 (p54), and CD2v genes of ASFV revealed that Genotype I, Serogroup 4, caused the initial outbreaks in these countries, followed by Genotype II, Serogroup 8. CVR profile analysis showed ASFV Genotype I with different variants, while Genotype II presented only one CVR variant. This is the first report of ASFV Genotype II in Burkina Faso, Cote d’Ivoire, and Mali. The introduction of ASFV Genotype II and its co-circulation with Genotype I in pig populations in these West African countries threatens food security and complicates control measures. Therefore, increased surveillance at international ports of entry, restrictions on live pig movements within the countries, and improved farm-level biosecurity measures are needed to control the further spread of the disease.</p>\n </div>","PeriodicalId":234,"journal":{"name":"Transboundary and Emerging Diseases","volume":"2025 1","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/tbed/5396227","citationCount":"0","resultStr":"{\"title\":\"Detection of African Swine Fever Virus Genotype II in West Africa (2020) and Its Co-Circulation With Endemic Genotype I: Implications for Pig Production\",\"authors\":\"Irene Kasindi Meki, Adeyinka Jeremy Adedeji, Lalidia Bruno Ouoba, Yao Mathurin Koffi, Adama Diakité, Tirumala B. K. Settypalli, Lamouni Habibata-Zerbo, Kouamé Valère Kouakou, Mohamed Adama Diakité, Charles Masembe, Moctar Sidi, Thierry Ouattara Douyeri, Fatoumata Dembelé, Helen E. Luka, Sandaogo Hamidou-Ouandaogo, Christiane Dembelé, Rebecca Weka, Gregorie Bazimo, Martin Dakouo, Toyin A. Olubade, Mariétou Guitti-Kindo, Chaka Traoré, Olushola Gamra, Dominique Guigma, Cheick Abou Kounta Sidibé, Dupe A. Hambolu, Drabo Dji-tombo Adama, Boubacar Madio dit Aladiogo Maïga, Mary A. Ogunleye, Ayokanmi Toluhi, Nanven Maurice, Emmanuel Couacy-Hymann, Pam D. Luka, Giovanni Cattoli, Charles E. Lamien\",\"doi\":\"10.1155/tbed/5396227\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n <p>African swine fever (ASF) is a highly devastating disease of domestic pigs caused by the ASF virus (ASFV). Historically, only ASFV Genotype I was known to circulate in West Africa. However, Genotype II has recently emerged in Nigeria, Ghana, and Benin for the first time. Between 2017 and 2023, suspected ASF outbreaks were reported in Burkina Faso, Côte d’Ivoire, Nigeria, and Mali. The source, extent, and spread of these ASF outbreaks remain unknown. Samples collected from 2017 to 2023 were analyzed using real-time qPCR and characterized using five ASFV gene segments: partial gene of the B464L (p72), full length E183L (p54), central variable region (CVR) within B602L, EP402R (CD2v), and intergenic region (IGR) between I73R and I329L genes. ASF was confirmed in 12 Nigerian states and in seven, eight, and two provinces of Burkina Faso, Côte d’Ivoire, and Mali, respectively. Phylogenetic analysis of B646L (p72), E183 (p54), and CD2v genes of ASFV revealed that Genotype I, Serogroup 4, caused the initial outbreaks in these countries, followed by Genotype II, Serogroup 8. CVR profile analysis showed ASFV Genotype I with different variants, while Genotype II presented only one CVR variant. 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Detection of African Swine Fever Virus Genotype II in West Africa (2020) and Its Co-Circulation With Endemic Genotype I: Implications for Pig Production
African swine fever (ASF) is a highly devastating disease of domestic pigs caused by the ASF virus (ASFV). Historically, only ASFV Genotype I was known to circulate in West Africa. However, Genotype II has recently emerged in Nigeria, Ghana, and Benin for the first time. Between 2017 and 2023, suspected ASF outbreaks were reported in Burkina Faso, Côte d’Ivoire, Nigeria, and Mali. The source, extent, and spread of these ASF outbreaks remain unknown. Samples collected from 2017 to 2023 were analyzed using real-time qPCR and characterized using five ASFV gene segments: partial gene of the B464L (p72), full length E183L (p54), central variable region (CVR) within B602L, EP402R (CD2v), and intergenic region (IGR) between I73R and I329L genes. ASF was confirmed in 12 Nigerian states and in seven, eight, and two provinces of Burkina Faso, Côte d’Ivoire, and Mali, respectively. Phylogenetic analysis of B646L (p72), E183 (p54), and CD2v genes of ASFV revealed that Genotype I, Serogroup 4, caused the initial outbreaks in these countries, followed by Genotype II, Serogroup 8. CVR profile analysis showed ASFV Genotype I with different variants, while Genotype II presented only one CVR variant. This is the first report of ASFV Genotype II in Burkina Faso, Cote d’Ivoire, and Mali. The introduction of ASFV Genotype II and its co-circulation with Genotype I in pig populations in these West African countries threatens food security and complicates control measures. Therefore, increased surveillance at international ports of entry, restrictions on live pig movements within the countries, and improved farm-level biosecurity measures are needed to control the further spread of the disease.
期刊介绍：
Transboundary and Emerging Diseases brings together in one place the latest research on infectious diseases considered to hold the greatest economic threat to animals and humans worldwide. The journal provides a venue for global research on their diagnosis, prevention and management, and for papers on public health, pathogenesis, epidemiology, statistical modeling, diagnostics, biosecurity issues, genomics, vaccine development and rapid communication of new outbreaks. Papers should include timely research approaches using state-of-the-art technologies. The editors encourage papers adopting a science-based approach on socio-economic and environmental factors influencing the management of the bio-security threat posed by these diseases, including risk analysis and disease spread modeling. Preference will be given to communications focusing on novel science-based approaches to controlling transboundary and emerging diseases. The following topics are generally considered out-of-scope, but decisions are made on a case-by-case basis (for example, studies on cryptic wildlife populations, and those on potential species extinctions):
Pathogen discovery: a common pathogen newly recognised in a specific country, or a new pathogen or genetic sequence for which there is little context about — or insights regarding — its emergence or spread.
Prevalence estimation surveys and risk factor studies based on survey (rather than longitudinal) methodology, except when such studies are unique. Surveys of knowledge, attitudes and practices are within scope.
Diagnostic test development if not accompanied by robust sensitivity and specificity estimation from field studies.
Studies focused only on laboratory methods in which relevance to disease emergence and spread is not obvious or can not be inferred (“pure research” type studies).
Narrative literature reviews which do not generate new knowledge. Systematic and scoping reviews, and meta-analyses are within scope.
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