设计用于模拟骨膜环境调节间充质干细胞命运的软气动装置（Adv. Healthcare Mater. 15/2025）

IF 10 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2025-06-09 DOI:10.1002/adhm.202570093

Gwang-Bum Im, Jae Gyeong Lee, Hosub Lim, Jae-Won Lee, Hyun Su Park, Yongju Kim, Nauman Asad, Hak-Rin Kim, Jeong Jae Wie, Suk Ho Bhang

{"title":"设计用于模拟骨膜环境调节间充质干细胞命运的软气动装置（Adv. Healthcare Mater. 15/2025）","authors":"Gwang-Bum Im, Jae Gyeong Lee, Hosub Lim, Jae-Won Lee, Hyun Su Park, Yongju Kim, Nauman Asad, Hak-Rin Kim, Jeong Jae Wie, Suk Ho Bhang","doi":"10.1002/adhm.202570093","DOIUrl":null,"url":null,"abstract":"<p><b>Soft Pneumatic Tissue Mimicking Device</b></p><p>In article 2403229, Jeong Jae Wie, Suk Ho Bhan, and co-workers introduce a cutting-edge soft pneumatic device (SPD) that mimics the complex mechanical forces of the periosteum during movement, bridging biomechanics and stem cell biology. By integrating shear stress, strain, and fluid dynamics, SPD directs mesenchymal stem/progenitor cell fate—promoting osteogenic differentiation under mild forces while inducing controlled detachment under higher loads. Unlike conventional systems, SPD preserves the extracellular matrix, offering a transformative platform for studying mechanotransduction, bone regeneration, and cell therapy.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"14 15","pages":""},"PeriodicalIF":10.0000,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202570093","citationCount":"0","resultStr":"{\"title\":\"Soft Pneumatic Device Designed to Mimic the Periosteal Environment for Regulating the Fate of Mesenchymal Stem Cells (Adv. Healthcare Mater. 15/2025)\",\"authors\":\"Gwang-Bum Im, Jae Gyeong Lee, Hosub Lim, Jae-Won Lee, Hyun Su Park, Yongju Kim, Nauman Asad, Hak-Rin Kim, Jeong Jae Wie, Suk Ho Bhang\",\"doi\":\"10.1002/adhm.202570093\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>Soft Pneumatic Tissue Mimicking Device</b></p><p>In article 2403229, Jeong Jae Wie, Suk Ho Bhan, and co-workers introduce a cutting-edge soft pneumatic device (SPD) that mimics the complex mechanical forces of the periosteum during movement, bridging biomechanics and stem cell biology. By integrating shear stress, strain, and fluid dynamics, SPD directs mesenchymal stem/progenitor cell fate—promoting osteogenic differentiation under mild forces while inducing controlled detachment under higher loads. Unlike conventional systems, SPD preserves the extracellular matrix, offering a transformative platform for studying mechanotransduction, bone regeneration, and cell therapy.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":113,\"journal\":{\"name\":\"Advanced Healthcare Materials\",\"volume\":\"14 15\",\"pages\":\"\"},\"PeriodicalIF\":10.0000,\"publicationDate\":\"2025-06-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202570093\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Healthcare Materials\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/adhm.202570093\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Healthcare Materials","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/adhm.202570093","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}

引用次数: 0

摘要

在文章2403229中，Jeong Jae Wie， Suk Ho Bhan及其同事介绍了一种尖端的软气动装置（SPD），该装置可以模拟运动过程中骨膜的复杂机械力，连接生物力学和干细胞生物学。通过整合剪切应力、应变和流体动力学，SPD指导间充质干细胞/祖细胞命运在温和的力下促进成骨分化，同时在高负荷下诱导受控脱离。与传统系统不同，SPD保留了细胞外基质，为研究机械转导、骨再生和细胞治疗提供了一个变革性的平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Soft Pneumatic Device Designed to Mimic the Periosteal Environment for Regulating the Fate of Mesenchymal Stem Cells (Adv. Healthcare Mater. 15/2025)

Soft Pneumatic Tissue Mimicking Device

In article 2403229, Jeong Jae Wie, Suk Ho Bhan, and co-workers introduce a cutting-edge soft pneumatic device (SPD) that mimics the complex mechanical forces of the periosteum during movement, bridging biomechanics and stem cell biology. By integrating shear stress, strain, and fluid dynamics, SPD directs mesenchymal stem/progenitor cell fate—promoting osteogenic differentiation under mild forces while inducing controlled detachment under higher loads. Unlike conventional systems, SPD preserves the extracellular matrix, offering a transformative platform for studying mechanotransduction, bone regeneration, and cell therapy.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.