组织工程中的Efferocytosis：促进组织修复和再生的新兴治疗策略的综合综述

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2025-06-09 DOI:10.1016/j.bioactmat.2025.05.026

Yue-Qi Zhang , Rong Nie , Zi-Yuan Feng , Ming-Hui Fan , Zhi-Xue Shen , Xiu-Zhen Zhang , Qing-Yi Zhang , Chen-Yu Zou , Ji-Ye Zhang , Kai Huang , Li-Ping Mou , Hui-Qi Xie

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引用次数: 0

摘要

这篇综合综述阐明了efferocytosis在组织修复和再生过程中的关键作用，同时系统地探索了通过组织工程策略调节efferocytosis来优化这些生物过程的创新方法。该手稿的结构是首先建立一个基本的了解efferocytosis，包括其核心概念，分子机制和生理功能在组织修复。随后，它提供了一个深入的分析，在组织修复级联过程中，efferocytosis在炎症反应调节中的调节作用。回顾的高潮在尖端组织工程应用的详细调查，专门设计操纵efferocytosis途径。最近研究的大量证据明确表明，efferocytosis是维持组织稳态和协调损伤修复机制的重要生物学过程。在这种情况下，组织工程已经成为一种变革性的方法，提供对efferocytosis增强，炎症解决和组织再生过程的精确控制。通过生物活性因子调控、先进支架材料和靶向细胞相互作用的复杂整合，组织工程平台建立了新的治疗范式，为治疗各种病理状况提供了前所未有的见解和创新策略。

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Efferocytosis in tissue engineering: A comprehensive review of emerging therapeutic strategies for enhanced tissue repair and regeneration

This comprehensive review elucidates the critical role of efferocytosis in tissue repair and regeneration processes, while systematically exploring innovative approaches through which tissue engineering strategies can modulate efferocytosis to optimize these biological processes. The manuscript is structured to first establish a fundamental understanding of efferocytosis, encompassing its core concepts, molecular mechanisms, and physiological functions within tissue repair. Subsequently, it provides an in-depth analysis of the regulatory role of efferocytosis in inflammatory response modulation during tissue repair cascades. The review culminates in a detailed investigation of cutting-edge tissue engineering applications specifically designed to manipulate efferocytosis pathways. Substantial evidence from recent studies has unequivocally demonstrated that efferocytosis serves as a crucial biological process in maintaining tissue homeostasis and orchestrating injury repair mechanisms. In this context, tissue engineering has emerged as a transformative approach, offering precise control over efferocytosis enhancement, inflammation resolution, and tissue regeneration processes. Through sophisticated integration of bioactive factor regulation, advanced scaffolding materials, and targeted cellular interactions, tissue engineering platforms have established novel therapeutic paradigms, providing unprecedented insights and innovative strategies for the treatment of diverse pathological conditions.

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.