雪冬糖浆对多囊卵巢综合征女性餐后血糖的影响：一项双盲随机临床试验

Q3 Nursing

Clinical Nutrition Open Science Pub Date : 2025-05-29 DOI:10.1016/j.nutos.2025.05.011

Fernanda Freitas Pereira , Miriam Verginia Lourenço , Gabriel Vendruscolo Pizo , Beatris Gomes Siqueira , Rita M. Moraes , Charles L. Cantrell , Mei Wang , Rosana Maria dos Reis , Anderson Marliere Navarro

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引用次数: 0

摘要

背景,目的多囊卵巢综合征（PCOS）是一种影响全球育龄妇女的高发内分泌疾病。重要的代谢改变、高血糖、胰岛素抵抗（IR）和糖代谢受损会加重多囊卵巢综合征，特别是在超重和肥胖的人群中。某些根茎类蔬菜，如雪莲的块根，显示出潜在的抗糖尿病活性，以改善人体健康。本研究评估了雪糕糖浆对超重或肥胖多囊卵巢综合征女性餐后血糖反应的影响。方法20例超重或肥胖合并多囊卵巢综合征（PCOS）患者进行为期15天的随机交叉试验，干预期5天，洗脱期3天。我们对日常食物消耗量进行了生化和人体测量学评估。亚贡糖浆和安慰剂分别在早餐、午餐和晚餐时服用。我们监测餐前、餐后立即、餐后1小时和餐后2小时的血糖。共对20例PCOS女性进行评估：60% （n=12）超重，40% （n=8）肥胖，平均年龄27.15（±5.92）岁。结果两组在食物消费方面差异无统计学意义(P <；0.05)。然而，血糖数据显示，一般餐后立即血糖（P= 0.007）和早餐和晚餐时的餐后立即血糖（P= 0.03和P= 0.034）存在差异。结论：研究结果表明，超重或肥胖的多囊卵巢综合征妇女在进餐时食用雪糕糖浆可能有助于缓解餐后立即血糖反应。这种效果可能有利于减少餐后葡萄糖波动。临床试验注册编号：rbr -104qgt7b。

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Effects of yacon syrup on postprandial blood glucose in women with polycystic ovary syndrome: A double-blind randomized clinical trial

Background & Aims

Polycystic Ovary Syndrome (PCOS) is a highly prevalent endocrine disorder that affects women of reproductive age worldwide. Important metabolic alterations, hyperglycemia, insulin resistance (IR), and impaired glucose metabolism aggravate PCOS, especially in those who are overweight and obese. Certain root vegetables, such as the tuberous root of yacon (Smallanthus sonchifolius), shows potential antidiabetic activity for improving human health. This study evaluates the effect of yacon syrup on postprandial blood glucose response in overweight or obese women with PCOS.

Methods

We conducted a randomized crossover trial lasting fifteen days, with 5 days of intervention and a washout period of 3 days, involving 20 patients diagnosed as overweight or obese with PCOS. We performed a biochemical and anthropometric evaluation of daily food consumption. Yacon syrup and placebo were administered at breakfast, lunch, and dinner. We monitored blood glucose pre-meal, immediate post-meal, 1 hour post-meal, and 2 hours post-meal. A total of 20 women with PCOS were evaluated: 60% (n=12) overweight and 40% (n=8) obese, with a mean age of 27.15 (±5.92) years.

Results

There were no significant differences in food consumption (P < 0.05). However, blood glucose data revealed differences in immediate postprandial blood glucose at meals in general (P = 0.007) and in immediate postprandial blood glucose at breakfast and dinner (P= 0.03 and P = 0.034, respectively).

Conclusion

The findings suggest that the consumption of yacon syrup as part of meals in overweight or obese women with PCOS may contribute to moderating immediate postprandial glycemic response. This effect could be beneficial in reducing glucose fluctuations following meals.