幽门后喂养改善了重症破伤风患者的营养状况，减少了喂养不耐受的发生率

IF 2.6 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-06-04 DOI:10.1016/j.clnesp.2025.05.047

Yanwei Rao , Yang Chen , Di Wang , Lijing Chen , Xinzao Xu , Cen Shen , Wenchao Duan , Yongjie Wang

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引用次数: 0

摘要

背景：严重破伤风患者表现出诸如咬关、破伤风痉挛和强直等临床特征，主要影响肌群，包括咬肌、竖脊肌、腹肌和肢体肌肉。本研究的主要目的是探讨在重症破伤风治疗过程中，幽门后喂养是否能提高患者的营养水平，减少喂养不耐受的发生。方法采用方便抽样法，选取2020年1月~ 2023年11月符合纳入标准的破伤风患者122例，分为鼻胃喂养组（NGF, n = 36）和鼻肠喂养组（NIF, n = 36）。收集基本资料，分析营养生化指标及不耐受频次。结果在第7天和第14天，NIF组的白蛋白（ALB）、总蛋白（TP）、前白蛋白（PA）和视黄醇结合蛋白（RBP）水平明显高于NGF组。同时，与NGF组相比，NIF组的营养不耐受发生率显著降低。结论幽门后喂养可提高重症破伤风患者的营养水平，减少喂养不耐受（腹泻、腹胀、呕吐）的发生。

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Post-pyloric feeding improves the nutritional status of severe tetanus patients and reduces the incidence of feeding intolerance

Background

Patients with severe tetanus exhibit clinical features such as trismus, tetanic spasms, and rigidity, primarily affecting muscle groups including masseter muscles, erector spinae muscles, abdominal muscles, and limb muscles. The main objective of this study is to investigate whether post-pyloric feeding can improve the nutritional level of patients and reduce the incidence of feeding intolerance during the treatment of severe tetanus.

Methods

A convenience sampling method was used to select 122 patients with tetanus who met the inclusion criteria from January 2020 to November 2023, and divided into groups that received Nasogastric feeding (NGF, n = 36) and Nasointestinal feeding (NIF, n = 36). Basic information was collected, nutritional biochemical indicators and frequency of intolerance were analyzed.

Results

By day 7 and 14, the NIF group exhibited significantly higher levels of Albumin (ALB), Total Protein (TP), Prealbumin (PA) and Retinol Binding Protein (RBP) compared to the NGF group. At the same time, the incidence of nutritional intolerance in the NIF group was significantly lower compared to the NGF group.

Conclusion

Post-pyloric feeding can improve the nutritional level of patients with severe tetanus and reduce the frequency of feeding intolerance (diarrhea, abdominal distension and vomiting).

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.