负载型寡肽合成羟基离子液体的设计与应用

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-05-08 DOI:10.1016/j.tetlet.2025.155645

Hao Ling, Shuaijun Ding, Jinzhe Chen, Zhitian Huang, Jiayi Wang, Yanqing Peng, Gonghua Song

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引用次数: 0

摘要

根据分离纯化效率对离子液体结构进行系统优化，建立了一种新型羟乙基咪唑型离子液体快速高效负载合成寡肽的策略。该方法结合了固相和液相合成的优点，既能保持反应条件均相，又有利于纯化过程，产物收率高。成功合成了[Leu5]-脑啡肽和[Met5]-脑啡肽（收率≥70%，纯度≥95%），证明了该方法的有效性。使用过的离子液体载体可有效回收。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Design and application of hydroxyl ionic liquids for the supported synthesis of oligopeptides

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Design and application of hydroxyl ionic liquids for the supported synthesis of oligopeptides

A strategy for the rapid and effective supported synthesis of oligopeptides using a novel hydroxyethyl imidazole-type ionic liquid was developed after systematically optimizing the ionic liquid structure depending on the separation and purification efficiency. This method, which incorporates the advantages of both solid- and liquid-phase synthesis, can not only maintain the homogeneous reaction conditions, but also facilitate the purification process with high product yield. The effectiveness of this approach was demonstrated by the successful synthesis of [Leu⁵]-enkephalin and [Met⁵]-enkephalin (yield ≥70 % and purity ≥95 %). The used ionic liquid support can be effectively recycled.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.