Continuous synergistic double imprinting idea based on MXene-nanocomposite membrane for efficient identification and isolation

Ti₃C₂Tx (MXene) has been highly sought after by researchers around the world due to its typical two-dimensional layered structural features and abundant surface groups. Herein, we fix MXene on the membrane by means of a decompression filtration device, and the formation of interlayer domain-limited channels helps to enhance the construction efficiency of imprinting sites. Herein, Ag-PDA@MXene@PDA@SiO₂-PVDF double imprinted hybrid matrix membranes (APMS-DIMs) were prepared using a synergistic double-imprinting strategy and effectively utilized to identify and isolate artemisinin (Ars). Above all, SiO₂-PVDF nanofibre membranes (NMs) was synthesized via electrostatic spinning and self-polymerization of dopamine (PDA) was carried out to construct the first layer of imprint. Meanwhile, PDA enhanced the oxidation resistance of MXene and the interfacial stability of SiO₂-PVDF NMs. The second layer imprint was then constructed on the surface of the MXene and within the interlayer channels. When Ars passed through the membrane, it was specifically recognized and adsorbed several times by the bilayer blotting sites constructed using the synergistic double imprinting strategy, which significantly enhanced the selective adsorption efficiency of Ars. Therefore, the rebinding ability (73.15 mg g⁻¹) and selectivity factors (β_{Artesunate/Ars} and β_{Dihydroartemisinin/Ars} were 4.47 and 3.93) of the membrane to Ars have been greatly improved. This study demonstrated that precise recognition sites were successfully constructed on APMS-DIMs with high levels of stability and recombination ability, which have potential for practical application.