Mohini Bryant-Ekstrand , Peter Luu , Thomas Gooding , Rachel Jaten , Andrew Thomas Lovering , Hans C. Haverkamp
{"title":"年轻、健康、娱乐活跃的男性和女性在COVID-19康复后的肺功能、弥散能力和强迫振荡测量","authors":"Mohini Bryant-Ekstrand , Peter Luu , Thomas Gooding , Rachel Jaten , Andrew Thomas Lovering , Hans C. Haverkamp","doi":"10.1016/j.ijregi.2025.100668","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to examine the long-term impact of COVID-19 on pulmonary function (spirometry and forced oscillometry technique, and lung diffusing capacity for carbon monoxide [DL<sub>CO</sub>]) in a large group of young, recreationally active adults.</div></div><div><h3>Methods</h3><div>A total of 71 participants (aged 21 years) who had recovered from a positive COVID-19 infection (COVID<sup>+</sup>) and 55 participants (aged 24 years) who had never tested positive for COVID-19 (COVID<sup>−</sup>) performed routine spirometry and DL<sub>CO</sub>. Some patients also completed forced oscillometry technique (<em>n</em> = 22 COVID<sup>+</sup>; <em>n</em> = 18 COVID<sup>−</sup>).</div></div><div><h3>Results</h3><div>The ratio of forced expiratory volume in 1 second to forced vital capacity (FEV<sub>1</sub>/FVC) and forced expiratory flow between 25% and 75% of FVC (FEF<sub>25-75%</sub>) were slightly but significantly lower in patients who were COVID<sup>+</sup> than those who were COVID<sup>−</sup> (FEV<sub>1</sub>/FVC = 93.6 ± 8.3 vs 96.9 ± 6.7%-predicted, <em>P</em> = 0.019; FEF<sub>25-75%</sub> = 86.0 ± 21.2 vs 94.5 ± 21.1%-predicted, <em>P</em> = 0.015, respectively). There were no associations between any pulmonary function variables or DL<sub>CO</sub> and the number of days between COVID-19 infection and testing.</div></div><div><h3>Conclusions</h3><div>Our findings provide evidence that pulmonary function and DL<sub>CO</sub> are largely preserved after recovery from mild COVID-19 in young, healthy, active men and women.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"15 ","pages":"Article 100668"},"PeriodicalIF":1.7000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pulmonary function, diffusing capacity, and forced oscillometry after recovery from COVID-19 in young, healthy, recreationally active men and women\",\"authors\":\"Mohini Bryant-Ekstrand , Peter Luu , Thomas Gooding , Rachel Jaten , Andrew Thomas Lovering , Hans C. Haverkamp\",\"doi\":\"10.1016/j.ijregi.2025.100668\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><div>This study aimed to examine the long-term impact of COVID-19 on pulmonary function (spirometry and forced oscillometry technique, and lung diffusing capacity for carbon monoxide [DL<sub>CO</sub>]) in a large group of young, recreationally active adults.</div></div><div><h3>Methods</h3><div>A total of 71 participants (aged 21 years) who had recovered from a positive COVID-19 infection (COVID<sup>+</sup>) and 55 participants (aged 24 years) who had never tested positive for COVID-19 (COVID<sup>−</sup>) performed routine spirometry and DL<sub>CO</sub>. Some patients also completed forced oscillometry technique (<em>n</em> = 22 COVID<sup>+</sup>; <em>n</em> = 18 COVID<sup>−</sup>).</div></div><div><h3>Results</h3><div>The ratio of forced expiratory volume in 1 second to forced vital capacity (FEV<sub>1</sub>/FVC) and forced expiratory flow between 25% and 75% of FVC (FEF<sub>25-75%</sub>) were slightly but significantly lower in patients who were COVID<sup>+</sup> than those who were COVID<sup>−</sup> (FEV<sub>1</sub>/FVC = 93.6 ± 8.3 vs 96.9 ± 6.7%-predicted, <em>P</em> = 0.019; FEF<sub>25-75%</sub> = 86.0 ± 21.2 vs 94.5 ± 21.1%-predicted, <em>P</em> = 0.015, respectively). There were no associations between any pulmonary function variables or DL<sub>CO</sub> and the number of days between COVID-19 infection and testing.</div></div><div><h3>Conclusions</h3><div>Our findings provide evidence that pulmonary function and DL<sub>CO</sub> are largely preserved after recovery from mild COVID-19 in young, healthy, active men and women.</div></div>\",\"PeriodicalId\":73335,\"journal\":{\"name\":\"IJID regions\",\"volume\":\"15 \",\"pages\":\"Article 100668\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IJID regions\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2772707625001031\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IJID regions","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772707625001031","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Pulmonary function, diffusing capacity, and forced oscillometry after recovery from COVID-19 in young, healthy, recreationally active men and women
Objectives
This study aimed to examine the long-term impact of COVID-19 on pulmonary function (spirometry and forced oscillometry technique, and lung diffusing capacity for carbon monoxide [DLCO]) in a large group of young, recreationally active adults.
Methods
A total of 71 participants (aged 21 years) who had recovered from a positive COVID-19 infection (COVID+) and 55 participants (aged 24 years) who had never tested positive for COVID-19 (COVID−) performed routine spirometry and DLCO. Some patients also completed forced oscillometry technique (n = 22 COVID+; n = 18 COVID−).
Results
The ratio of forced expiratory volume in 1 second to forced vital capacity (FEV1/FVC) and forced expiratory flow between 25% and 75% of FVC (FEF25-75%) were slightly but significantly lower in patients who were COVID+ than those who were COVID− (FEV1/FVC = 93.6 ± 8.3 vs 96.9 ± 6.7%-predicted, P = 0.019; FEF25-75% = 86.0 ± 21.2 vs 94.5 ± 21.1%-predicted, P = 0.015, respectively). There were no associations between any pulmonary function variables or DLCO and the number of days between COVID-19 infection and testing.
Conclusions
Our findings provide evidence that pulmonary function and DLCO are largely preserved after recovery from mild COVID-19 in young, healthy, active men and women.
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