Cu2O量子点重新定义可见光下一分钟病原体灭活的光动力疗法

Q1 Environmental Science

Case Studies in Chemical and Environmental Engineering Pub Date : 2025-06-03 DOI:10.1016/j.cscee.2025.101248

Azzah Dyah Pramata , Farhan Aryo Hutomo , Febriyansyah Saputra , Paundra Rizky Pratama , Taras Geonovive De Yenarosa , Sutarsis , Sigit Tri Wicaksono , Agung Purniawan , Revianny Nidom , Shao-Yang Hu

{"title":"Cu2O量子点重新定义可见光下一分钟病原体灭活的光动力疗法","authors":"Azzah Dyah Pramata , Farhan Aryo Hutomo , Febriyansyah Saputra , Paundra Rizky Pratama , Taras Geonovive De Yenarosa , Sutarsis , Sigit Tri Wicaksono , Agung Purniawan , Revianny Nidom , Shao-Yang Hu","doi":"10.1016/j.cscee.2025.101248","DOIUrl":null,"url":null,"abstract":"<div><div>This work utilizes tailored – Cu<sub>2</sub>O quantum dots (QDs) to demonstrate unprecedented pathogen photo-inactivation. The superior ROS production of the QDs synthesized at 180 °C with a size of 8.10 nm resulted in a 99.98 % reduction of MRSA, 99.78 % of <em>Klebsiella pneumoniae</em>, and 98.92 % of SARS-CoV Delta within 1 min under visible light. Cu<sub>2</sub>O QDs efficiently reduced 99.25 % viability of 4T1 cancer cells in 15 min while maintaining more than 85 % viability in healthy HEK 293 cells, underlining its selectivity. This finding may establish Cu<sub>2</sub>O QDs as the next-generation anti-pathogen agents for advanced photodynamic therapy (PDT), biomedical sterilization, and hospital applications.</div></div>","PeriodicalId":34388,"journal":{"name":"Case Studies in Chemical and Environmental Engineering","volume":"12 ","pages":"Article 101248"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cu2O quantum dots redefining photodynamic therapy with one-minute pathogen inactivation under visible light\",\"authors\":\"Azzah Dyah Pramata , Farhan Aryo Hutomo , Febriyansyah Saputra , Paundra Rizky Pratama , Taras Geonovive De Yenarosa , Sutarsis , Sigit Tri Wicaksono , Agung Purniawan , Revianny Nidom , Shao-Yang Hu\",\"doi\":\"10.1016/j.cscee.2025.101248\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>This work utilizes tailored – Cu<sub>2</sub>O quantum dots (QDs) to demonstrate unprecedented pathogen photo-inactivation. The superior ROS production of the QDs synthesized at 180 °C with a size of 8.10 nm resulted in a 99.98 % reduction of MRSA, 99.78 % of <em>Klebsiella pneumoniae</em>, and 98.92 % of SARS-CoV Delta within 1 min under visible light. Cu<sub>2</sub>O QDs efficiently reduced 99.25 % viability of 4T1 cancer cells in 15 min while maintaining more than 85 % viability in healthy HEK 293 cells, underlining its selectivity. This finding may establish Cu<sub>2</sub>O QDs as the next-generation anti-pathogen agents for advanced photodynamic therapy (PDT), biomedical sterilization, and hospital applications.</div></div>\",\"PeriodicalId\":34388,\"journal\":{\"name\":\"Case Studies in Chemical and Environmental Engineering\",\"volume\":\"12 \",\"pages\":\"Article 101248\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Case Studies in Chemical and Environmental Engineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666016425001550\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Environmental Science\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Case Studies in Chemical and Environmental Engineering","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666016425001550","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Environmental Science","Score":null,"Total":0}

引用次数: 0

摘要

这项工作利用定制的Cu2O量子点（QDs）来展示前所未有的病原体光失活。在180°C下合成的量子点（尺寸为8.10 nm）具有较高的ROS产量，在可见光下，1 min内MRSA降低99.98%，肺炎克雷伯菌降低99.78%，SARS-CoV δ降低98.92%。Cu2O QDs在15分钟内有效降低4T1癌细胞99.25%的活力，而在健康的HEK 293细胞中保持85%以上的活力，表明其选择性。这一发现可能使Cu2O量子点成为先进光动力治疗（PDT）、生物医学灭菌和医院应用的下一代抗病原体药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Cu2O quantum dots redefining photodynamic therapy with one-minute pathogen inactivation under visible light

This work utilizes tailored – Cu₂O quantum dots (QDs) to demonstrate unprecedented pathogen photo-inactivation. The superior ROS production of the QDs synthesized at 180 °C with a size of 8.10 nm resulted in a 99.98 % reduction of MRSA, 99.78 % of Klebsiella pneumoniae, and 98.92 % of SARS-CoV Delta within 1 min under visible light. Cu₂O QDs efficiently reduced 99.25 % viability of 4T1 cancer cells in 15 min while maintaining more than 85 % viability in healthy HEK 293 cells, underlining its selectivity. This finding may establish Cu₂O QDs as the next-generation anti-pathogen agents for advanced photodynamic therapy (PDT), biomedical sterilization, and hospital applications.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊