{"title":"静电纺丝电活性组织工程支架的策略及应用研究进展","authors":"Yixun Li, Xinyu Li, Zhiwei Liu, Yuehua Wang* and Tifeng Jiao*, ","doi":"10.1021/acsbiomaterials.5c0014210.1021/acsbiomaterials.5c00142","DOIUrl":null,"url":null,"abstract":"<p >Conductive biomaterials not only have appropriate conductivity but also usually have good antibacterial properties and photothermal effects, so they are widely used in tissue engineering scaffolds. Conductive biomaterials can conduct endogenous or exogenous electrical signals, thus affecting the growth, migration, infiltration, and differentiation of cells. An electrospun nanofiber is an ideal kind of conductive substance carrier that can mimic the extracellular matrix (ECM) to further promote cell growth and migration. In this Review, we summarize the application of electrospinning electroactive tissue engineering scaffolds, discuss the advantages and disadvantages of various electrospinning methods, organize the characteristics of commonly used conductive biomaterials such as polyaniline (PANI), polypyrrole (PPy), poly(3,4-ethylene dioxythiophene) (PEDOT), carbon-based nanomaterials, and MXenes and their application in the tissue engineering field, and finally propose the application prospects and future of tissue engineering with conductive biomaterials.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 6","pages":"3182–3200 3182–3200"},"PeriodicalIF":5.4000,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recent Progress in the Strategies and Applications of Electrospinning Electroactive Tissue Engineering Scaffolds\",\"authors\":\"Yixun Li, Xinyu Li, Zhiwei Liu, Yuehua Wang* and Tifeng Jiao*, \",\"doi\":\"10.1021/acsbiomaterials.5c0014210.1021/acsbiomaterials.5c00142\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Conductive biomaterials not only have appropriate conductivity but also usually have good antibacterial properties and photothermal effects, so they are widely used in tissue engineering scaffolds. Conductive biomaterials can conduct endogenous or exogenous electrical signals, thus affecting the growth, migration, infiltration, and differentiation of cells. An electrospun nanofiber is an ideal kind of conductive substance carrier that can mimic the extracellular matrix (ECM) to further promote cell growth and migration. In this Review, we summarize the application of electrospinning electroactive tissue engineering scaffolds, discuss the advantages and disadvantages of various electrospinning methods, organize the characteristics of commonly used conductive biomaterials such as polyaniline (PANI), polypyrrole (PPy), poly(3,4-ethylene dioxythiophene) (PEDOT), carbon-based nanomaterials, and MXenes and their application in the tissue engineering field, and finally propose the application prospects and future of tissue engineering with conductive biomaterials.</p>\",\"PeriodicalId\":8,\"journal\":{\"name\":\"ACS Biomaterials Science & Engineering\",\"volume\":\"11 6\",\"pages\":\"3182–3200 3182–3200\"},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2025-05-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Biomaterials Science & Engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acsbiomaterials.5c00142\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Biomaterials Science & Engineering","FirstCategoryId":"5","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsbiomaterials.5c00142","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Recent Progress in the Strategies and Applications of Electrospinning Electroactive Tissue Engineering Scaffolds
Conductive biomaterials not only have appropriate conductivity but also usually have good antibacterial properties and photothermal effects, so they are widely used in tissue engineering scaffolds. Conductive biomaterials can conduct endogenous or exogenous electrical signals, thus affecting the growth, migration, infiltration, and differentiation of cells. An electrospun nanofiber is an ideal kind of conductive substance carrier that can mimic the extracellular matrix (ECM) to further promote cell growth and migration. In this Review, we summarize the application of electrospinning electroactive tissue engineering scaffolds, discuss the advantages and disadvantages of various electrospinning methods, organize the characteristics of commonly used conductive biomaterials such as polyaniline (PANI), polypyrrole (PPy), poly(3,4-ethylene dioxythiophene) (PEDOT), carbon-based nanomaterials, and MXenes and their application in the tissue engineering field, and finally propose the application prospects and future of tissue engineering with conductive biomaterials.
期刊介绍：
ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics:
Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology
Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions
Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis
Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering
Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends
Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring
Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration
Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials
Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture
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