采用“懒惰”的方法确定KCNB2是SHH-MB维持的调节因子

IF 10.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2025-06-09 DOI:10.1016/j.devcel.2025.04.016

Jaldeep Langhnoja, Timothy N. Phoenix

引用次数: 0

摘要

破译基因改变在肿瘤发生和维持中的作用仍然是一个重大挑战。在这一期的Developmental Cell中，Fan等人利用Lazy Piggy体内遗传筛选系统发现钾通道，即KCNB2，是sonic hedgehog (SHH)-髓母细胞瘤（MB）维持的关键调节因子，提供了一个治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Taking the “lazy” way identifies KCNB2 as a regulator of SHH-MB maintenance

Deciphering the role of genetic alterations in tumor initiation and maintenance remains a significant challenge. In this issue of Developmental Cell, Fan et al. identify potassium channels, namely KCNB2, as critical regulators of sonic hedgehog (SHH)-medulloblastoma (MB) maintenance using the Lazy Piggy in vivo genetic screening system, providing a therapeutic target.

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.