Lucia C Strader, Tianyuan Chen, Xinnian Dong, David Edwards, Sridevi Sureshkumar, Sureshkumar Balasubramanian, Mauricio S Antunes, Lili Zebluim, Patarasuda Chaisupa, R Clay Wright
{"title":"拟南芥基础研究的核心生物学原理和工具","authors":"Lucia C Strader, Tianyuan Chen, Xinnian Dong, David Edwards, Sridevi Sureshkumar, Sureshkumar Balasubramanian, Mauricio S Antunes, Lili Zebluim, Patarasuda Chaisupa, R Clay Wright","doi":"10.1093/plcell/koaf141","DOIUrl":null,"url":null,"abstract":"The model plant Arabidopsis thaliana has been a cornerstone of research in plant biology, contributing transformative insights into fundamental biological processes across eukaryotes. In this vignette, we explore the role of Arabidopsis in elucidating immune mechanisms, where plant studies have informed mammalian immunity and translational regulation. We discuss how Arabidopsis-driven advancements in pangenomics and repeat expansions have reshaped our understanding of genomic variability and its implications for diseases like Friedreich's ataxia. Breakthroughs in synthetic biology and bioproduction underscore Arabidopsis’ role as a testbed for engineering specialized metabolites and advancing biotechnological applications. Finally, we examine how the development of tools like Auxin-Inducible Degradation (AID) has extended beyond plant research, providing critical methodologies to study protein function and develop novel therapeutics.","PeriodicalId":501012,"journal":{"name":"The Plant Cell","volume":"85 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Core biological principles and tools stemming from basic Arabidopsis research\",\"authors\":\"Lucia C Strader, Tianyuan Chen, Xinnian Dong, David Edwards, Sridevi Sureshkumar, Sureshkumar Balasubramanian, Mauricio S Antunes, Lili Zebluim, Patarasuda Chaisupa, R Clay Wright\",\"doi\":\"10.1093/plcell/koaf141\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The model plant Arabidopsis thaliana has been a cornerstone of research in plant biology, contributing transformative insights into fundamental biological processes across eukaryotes. In this vignette, we explore the role of Arabidopsis in elucidating immune mechanisms, where plant studies have informed mammalian immunity and translational regulation. We discuss how Arabidopsis-driven advancements in pangenomics and repeat expansions have reshaped our understanding of genomic variability and its implications for diseases like Friedreich's ataxia. Breakthroughs in synthetic biology and bioproduction underscore Arabidopsis’ role as a testbed for engineering specialized metabolites and advancing biotechnological applications. Finally, we examine how the development of tools like Auxin-Inducible Degradation (AID) has extended beyond plant research, providing critical methodologies to study protein function and develop novel therapeutics.\",\"PeriodicalId\":501012,\"journal\":{\"name\":\"The Plant Cell\",\"volume\":\"85 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Plant Cell\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/plcell/koaf141\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Plant Cell","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/plcell/koaf141","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Core biological principles and tools stemming from basic Arabidopsis research
The model plant Arabidopsis thaliana has been a cornerstone of research in plant biology, contributing transformative insights into fundamental biological processes across eukaryotes. In this vignette, we explore the role of Arabidopsis in elucidating immune mechanisms, where plant studies have informed mammalian immunity and translational regulation. We discuss how Arabidopsis-driven advancements in pangenomics and repeat expansions have reshaped our understanding of genomic variability and its implications for diseases like Friedreich's ataxia. Breakthroughs in synthetic biology and bioproduction underscore Arabidopsis’ role as a testbed for engineering specialized metabolites and advancing biotechnological applications. Finally, we examine how the development of tools like Auxin-Inducible Degradation (AID) has extended beyond plant research, providing critical methodologies to study protein function and develop novel therapeutics.