动脉自旋标记成像检测头颈部副神经节瘤的敏感性。

Yannan Yu, Brian Q Tsui, Christine M Glastonbury, Xin Cynthia Wu
{"title":"动脉自旋标记成像检测头颈部副神经节瘤的敏感性。","authors":"Yannan Yu, Brian Q Tsui, Christine M Glastonbury, Xin Cynthia Wu","doi":"10.3174/ajnr.A8727","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and purpose: </strong>Head and neck paragangliomas (HNPGs) are rare neuroendocrine tumors whose hypervascular nature allows differentiation from many other head and neck neoplasms. We aimed to investigate the sensitivity of arterial spin-labeling (ASL) MR sequences for the detection of HNPGs.</p><p><strong>Materials and methods: </strong>All head and neck MR examinations performed at a single tertiary institution between 2015 and 2023 were searched. Studies using ASL sequences that indicated either clinical suspicion for or ultimate imaging diagnosis of HNPG were identified. These studies were independently reviewed by 2 neuroradiologists blinded to the original radiology reports to determine, in a stepwise fashion, the following: 1) whether there was asymmetrically elevated blood flow on ASL imaging, 2) whether ASL findings correlated with lesions identifiable on conventional anatomic images, and 3) whether lesions likely reflected paragangliomas on the basis of correlations with clinical, laboratory, pathology, and other radiology data (Disagreement between raters was resolved by consensus.). The Cohen κ coefficient and the sensitivity of ASL in identifying HNPGs were calculated.</p><p><strong>Results: </strong>Eighty-four patients were included in the analysis (mean age, 54 [SD, 14] years and 47 women). Thirty patients had lesions confirmed or found likely to be HNPG, and 54 patients had lesions found unlikely to be HNPG or had no identifiable lesion. Among 46 of 84 patients with ASL blood flow asymmetry, 43 (93%) had lesions correlated with a lesion identifiable on anatomic imaging. Asymmetrically elevated ASL blood flow that correlated with a lesion demonstrated a sensitivity of 100% for reader A and 97% for reader B for identifying HNPG. The Cohen κ coefficient was 0.90 (SD, 0.11) between the 2 readers (<i>P</i> < .001). Among 18 cases with pathology- or dotatate PET-proved HNPG, the sensitivity was 100% for reader A and 94% for reader B.</p><p><strong>Conclusions: </strong>Asymmetrically elevated blood flow on ASL imaging demonstrates high sensitivity for the detection of HNPG, with almost perfect interrater agreement.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":"1458-1463"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Sensitivity of Arterial Spin-Labeling Imaging for Detection of Head and Neck Paragangliomas.\",\"authors\":\"Yannan Yu, Brian Q Tsui, Christine M Glastonbury, Xin Cynthia Wu\",\"doi\":\"10.3174/ajnr.A8727\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and purpose: </strong>Head and neck paragangliomas (HNPGs) are rare neuroendocrine tumors whose hypervascular nature allows differentiation from many other head and neck neoplasms. We aimed to investigate the sensitivity of arterial spin-labeling (ASL) MR sequences for the detection of HNPGs.</p><p><strong>Materials and methods: </strong>All head and neck MR examinations performed at a single tertiary institution between 2015 and 2023 were searched. Studies using ASL sequences that indicated either clinical suspicion for or ultimate imaging diagnosis of HNPG were identified. These studies were independently reviewed by 2 neuroradiologists blinded to the original radiology reports to determine, in a stepwise fashion, the following: 1) whether there was asymmetrically elevated blood flow on ASL imaging, 2) whether ASL findings correlated with lesions identifiable on conventional anatomic images, and 3) whether lesions likely reflected paragangliomas on the basis of correlations with clinical, laboratory, pathology, and other radiology data (Disagreement between raters was resolved by consensus.). The Cohen κ coefficient and the sensitivity of ASL in identifying HNPGs were calculated.</p><p><strong>Results: </strong>Eighty-four patients were included in the analysis (mean age, 54 [SD, 14] years and 47 women). Thirty patients had lesions confirmed or found likely to be HNPG, and 54 patients had lesions found unlikely to be HNPG or had no identifiable lesion. Among 46 of 84 patients with ASL blood flow asymmetry, 43 (93%) had lesions correlated with a lesion identifiable on anatomic imaging. Asymmetrically elevated ASL blood flow that correlated with a lesion demonstrated a sensitivity of 100% for reader A and 97% for reader B for identifying HNPG. The Cohen κ coefficient was 0.90 (SD, 0.11) between the 2 readers (<i>P</i> < .001). Among 18 cases with pathology- or dotatate PET-proved HNPG, the sensitivity was 100% for reader A and 94% for reader B.</p><p><strong>Conclusions: </strong>Asymmetrically elevated blood flow on ASL imaging demonstrates high sensitivity for the detection of HNPG, with almost perfect interrater agreement.</p>\",\"PeriodicalId\":93863,\"journal\":{\"name\":\"AJNR. American journal of neuroradiology\",\"volume\":\" \",\"pages\":\"1458-1463\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"AJNR. American journal of neuroradiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3174/ajnr.A8727\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"AJNR. American journal of neuroradiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3174/ajnr.A8727","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

背景与目的:头颈部副神经节瘤(hnpg)是一种罕见的神经内分泌肿瘤,其高血管性使其能够与其他头颈部肿瘤区分开来。我们的目的是研究动脉自旋标记(ASL) MR序列检测hnpg的敏感性。材料和方法:检索2015年至2023年间在一所高等教育机构进行的所有头颈部MR检查。使用ASL序列的研究表明临床怀疑或最终影像学诊断为HNPG。这些研究由两名对原始放射学报告不知情的神经放射学家独立审查,以逐步确定以下内容:1) ASL影像学上是否存在不对称的血流量升高,2)ASL的发现是否与常规解剖图像上可识别的病变相关,3)根据临床、实验室、病理和其他放射学数据的相关性,病变是否可能反映副神经节瘤(评分者之间的分歧得到一致解决)。计算Cohen κ系数和ASL识别hnpg的敏感性。结果:84例患者纳入分析,平均年龄54 [SD, 14]岁,女性47例。30例患者的病变确诊或发现可能是HNPG, 54例患者的病变发现不太可能是HNPG或没有可识别的病变。在84例ASL血流不对称患者中的46例中,43例(93%)的病变与解剖影像学上可识别的病变相关。与病变相关的非对称ASL血流量升高表明阅读器a识别HNPG的灵敏度为100%,阅读器B识别HNPG的灵敏度为97%。两组间的Cohen κ系数为0.90 (SD, 0.11),差异有统计学意义(P < 0.001)。在18例病理或证实pet证实的HNPG病例中,读写器A的敏感性为100%,读写器b的敏感性为94%。结论:ASL成像不对称血流量升高显示了HNPG检测的高敏感性,几乎完全一致。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Sensitivity of Arterial Spin-Labeling Imaging for Detection of Head and Neck Paragangliomas.

Background and purpose: Head and neck paragangliomas (HNPGs) are rare neuroendocrine tumors whose hypervascular nature allows differentiation from many other head and neck neoplasms. We aimed to investigate the sensitivity of arterial spin-labeling (ASL) MR sequences for the detection of HNPGs.

Materials and methods: All head and neck MR examinations performed at a single tertiary institution between 2015 and 2023 were searched. Studies using ASL sequences that indicated either clinical suspicion for or ultimate imaging diagnosis of HNPG were identified. These studies were independently reviewed by 2 neuroradiologists blinded to the original radiology reports to determine, in a stepwise fashion, the following: 1) whether there was asymmetrically elevated blood flow on ASL imaging, 2) whether ASL findings correlated with lesions identifiable on conventional anatomic images, and 3) whether lesions likely reflected paragangliomas on the basis of correlations with clinical, laboratory, pathology, and other radiology data (Disagreement between raters was resolved by consensus.). The Cohen κ coefficient and the sensitivity of ASL in identifying HNPGs were calculated.

Results: Eighty-four patients were included in the analysis (mean age, 54 [SD, 14] years and 47 women). Thirty patients had lesions confirmed or found likely to be HNPG, and 54 patients had lesions found unlikely to be HNPG or had no identifiable lesion. Among 46 of 84 patients with ASL blood flow asymmetry, 43 (93%) had lesions correlated with a lesion identifiable on anatomic imaging. Asymmetrically elevated ASL blood flow that correlated with a lesion demonstrated a sensitivity of 100% for reader A and 97% for reader B for identifying HNPG. The Cohen κ coefficient was 0.90 (SD, 0.11) between the 2 readers (P < .001). Among 18 cases with pathology- or dotatate PET-proved HNPG, the sensitivity was 100% for reader A and 94% for reader B.

Conclusions: Asymmetrically elevated blood flow on ASL imaging demonstrates high sensitivity for the detection of HNPG, with almost perfect interrater agreement.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信