Bo-Min Kim, So-Yeon Ryu, Mi-Ah Han, Seong-Woo Choi
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Multivariate analyses were conducted, adjusting for confounders such as sex, age, income, education, smoking, alcohol consumption, physical activity, and waist circumference.</p><p><strong>Results: </strong>Among the study population, 1,784 participants (37.0%) were diagnosed with MetS. hs-CRP levels were significantly higher in individuals with MetS (1.06 mg/L vs. 0.79 mg/L, p < 0.001) and increased with the number of MetS components (p for trend < 0.001). Significant associations were observed between hs-CRP and all MetS components. However, after adjusting for waist circumference, these associations lost statistical significance.</p><p><strong>Conclusion: </strong>This study confirms a strong association between hs-CRP and MetS, primarily influenced by central obesity. The findings highlight abdominal obesity as a key contributor to systemic inflammation in MetS. Further longitudinal studies are needed to explore the causal relationship and underlying mechanisms.</p>","PeriodicalId":48730,"journal":{"name":"Journal of Physiological Anthropology","volume":"44 1","pages":"16"},"PeriodicalIF":2.1000,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139091/pdf/","citationCount":"0","resultStr":"{\"title\":\"Loss of significant association between high-sensitivity C-reactive protein (hs-CRP) and metabolic syndrome after adjustment for waist circumference found in 2022 Korea National Health and Nutrition Examination Survey data.\",\"authors\":\"Bo-Min Kim, So-Yeon Ryu, Mi-Ah Han, Seong-Woo Choi\",\"doi\":\"10.1186/s40101-025-00396-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that increase the risk of cardiovascular disease and type 2 diabetes. 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引用次数: 0
摘要
背景:代谢综合征(MetS)是一组代谢异常,增加心血管疾病和2型糖尿病的风险。高敏c反应蛋白(hs-CRP)是全身性炎症的生物标志物,但其与MetS及其组分的关系尚不清楚。本研究调查了具有代表性的韩国人群中hs-CRP与MetS之间的关系。方法:利用2022年韩国国家健康和营养检查调查(KNHANES)的数据,我们分析了4,823名成年人。MetS是根据修订的NCEP-ATP III标准定义的。进行多变量分析,调整混杂因素,如性别、年龄、收入、教育、吸烟、饮酒、体育活动和腰围。结果:在研究人群中,1784名参与者(37.0%)被诊断为MetS。MetS患者的hs-CRP水平显著升高(1.06 mg/L vs. 0.79 mg/L)。结论:本研究证实hs-CRP与MetS之间存在强烈关联,主要受中心肥胖的影响。研究结果强调,腹部肥胖是MetS全身性炎症的关键因素。需要进一步的纵向研究来探索因果关系和潜在的机制。
Loss of significant association between high-sensitivity C-reactive protein (hs-CRP) and metabolic syndrome after adjustment for waist circumference found in 2022 Korea National Health and Nutrition Examination Survey data.
Background: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that increase the risk of cardiovascular disease and type 2 diabetes. High-sensitivity C-reactive protein (hs-CRP) is a biomarker of systemic inflammation, but its relationship with MetS and its components remains unclear. This study investigates the association between hs-CRP and MetS in a representative Korean population.
Methods: Using data from the 2022 Korea National Health and Nutrition Examination Survey (KNHANES), we analyzed 4,823 adults. MetS was defined according to revised NCEP-ATP III criteria. Multivariate analyses were conducted, adjusting for confounders such as sex, age, income, education, smoking, alcohol consumption, physical activity, and waist circumference.
Results: Among the study population, 1,784 participants (37.0%) were diagnosed with MetS. hs-CRP levels were significantly higher in individuals with MetS (1.06 mg/L vs. 0.79 mg/L, p < 0.001) and increased with the number of MetS components (p for trend < 0.001). Significant associations were observed between hs-CRP and all MetS components. However, after adjusting for waist circumference, these associations lost statistical significance.
Conclusion: This study confirms a strong association between hs-CRP and MetS, primarily influenced by central obesity. The findings highlight abdominal obesity as a key contributor to systemic inflammation in MetS. Further longitudinal studies are needed to explore the causal relationship and underlying mechanisms.
期刊介绍:
Journal of Physiological Anthropology (JPA) is an open access, peer-reviewed journal that publishes research on the physiological functions of modern mankind, with an emphasis on the physical and bio-cultural effects on human adaptability to the current environment.
The objective of JPA is to evaluate physiological adaptations to modern living environments, and to publish research from different scientific fields concerned with environmental impact on human life.
Topic areas include, but are not limited to:
environmental physiology
bio-cultural environment
living environment
epigenetic adaptation
development and growth
age and sex differences
nutrition and morphology
physical fitness and health
Journal of Physiological Anthropology is the official journal of the Japan Society of Physiological Anthropology.