{"title":"CCBs治疗发热伴血小板减少综合征合并高血压的临床疗效分析。","authors":"Ziruo Ge, Chenxi Zhao, Yanli Xu, Xiaoyu Xue, Wei Pan, Wei Zhang, Zhihai Chen, Ling Lin, Di Tian","doi":"10.1186/s12985-025-02818-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Calcium channel blockers (CCBs), commonly used in the treatment of various cardiovascular diseases, have shown promising potential in inhibiting the formation of viral inclusion bodies by lowering the level of intracellular Ca2+, thereby reducing viral replication. We conducted a retrospective single-center cohort study of SFTS patients with hypertension to assess the impact of CCB therapy on SFTS.</p><p><strong>Methods: </strong>SFTS patients with hypertension treated in Qishan Hospital of Yantai from May 1, 2018, to December 31, 2022, were included. According to the admission criteria, 94 patients with SFTS were divided into the CCBs group (N = 30) and the control group (patients who took other antihypertensive drugs) (N = 64). We observed the severity of the disease, fatality rate, nucleic acid conversion time, nucleic acid's positive rate, and the clinical improvement of the two groups. The effects of different CCBs on nucleic acid conversion were evaluated.</p><p><strong>Results: </strong>There was a significant difference in the severity rate between the CCBs and control groups (63.3% vs. 82.8%, P = 0.038). The time of nucleic acid conversion in the CCBs group was significantly shorter than in the control group (P = 0.001). The nucleic acid negative conversion curve differed between the two groups (Log Rank P = 0.010), and the CCBs group was better. The frequency of vomiting and nervous system symptoms in the CCBs group was significantly lower than in the control group (P = 0.049,0.038), and the platelet level was significantly higher in the former than in the latter (P = 0.015). The conversion rate of nucleic acid in patients taking nifedipine was significantly higher than that in patients taking other CCBs (p = 0.036).</p><p><strong>Conclusions: </strong>Our research indicates that CCBs may aid in decreasing disease severity, easing clinical symptoms, and potentially slowing the advancement to severe illness in patients with SFTS.</p>","PeriodicalId":23616,"journal":{"name":"Virology Journal","volume":"22 1","pages":"184"},"PeriodicalIF":4.0000,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142868/pdf/","citationCount":"0","resultStr":"{\"title\":\"Analysis of the clinical efficacy of CCBs in patients with severe fever with thrombocytopenia syndrome combined with hypertension.\",\"authors\":\"Ziruo Ge, Chenxi Zhao, Yanli Xu, Xiaoyu Xue, Wei Pan, Wei Zhang, Zhihai Chen, Ling Lin, Di Tian\",\"doi\":\"10.1186/s12985-025-02818-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Calcium channel blockers (CCBs), commonly used in the treatment of various cardiovascular diseases, have shown promising potential in inhibiting the formation of viral inclusion bodies by lowering the level of intracellular Ca2+, thereby reducing viral replication. We conducted a retrospective single-center cohort study of SFTS patients with hypertension to assess the impact of CCB therapy on SFTS.</p><p><strong>Methods: </strong>SFTS patients with hypertension treated in Qishan Hospital of Yantai from May 1, 2018, to December 31, 2022, were included. According to the admission criteria, 94 patients with SFTS were divided into the CCBs group (N = 30) and the control group (patients who took other antihypertensive drugs) (N = 64). We observed the severity of the disease, fatality rate, nucleic acid conversion time, nucleic acid's positive rate, and the clinical improvement of the two groups. The effects of different CCBs on nucleic acid conversion were evaluated.</p><p><strong>Results: </strong>There was a significant difference in the severity rate between the CCBs and control groups (63.3% vs. 82.8%, P = 0.038). The time of nucleic acid conversion in the CCBs group was significantly shorter than in the control group (P = 0.001). The nucleic acid negative conversion curve differed between the two groups (Log Rank P = 0.010), and the CCBs group was better. The frequency of vomiting and nervous system symptoms in the CCBs group was significantly lower than in the control group (P = 0.049,0.038), and the platelet level was significantly higher in the former than in the latter (P = 0.015). The conversion rate of nucleic acid in patients taking nifedipine was significantly higher than that in patients taking other CCBs (p = 0.036).</p><p><strong>Conclusions: </strong>Our research indicates that CCBs may aid in decreasing disease severity, easing clinical symptoms, and potentially slowing the advancement to severe illness in patients with SFTS.</p>\",\"PeriodicalId\":23616,\"journal\":{\"name\":\"Virology Journal\",\"volume\":\"22 1\",\"pages\":\"184\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-06-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142868/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Virology Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12985-025-02818-3\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VIROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Virology Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12985-025-02818-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VIROLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景:钙通道阻滞剂(CCBs)通常用于治疗各种心血管疾病,通过降低细胞内Ca2+水平抑制病毒包涵体的形成,从而减少病毒复制,显示出良好的潜力。我们对伴有高血压的SFTS患者进行了一项回顾性单中心队列研究,以评估CCB治疗对SFTS的影响。方法:选取烟台岐山医院2018年5月1日至2022年12月31日收治的SFTS高血压患者。根据入院标准将94例SFTS患者分为CCBs组(N = 30)和对照组(服用其他降压药物的患者)(N = 64)。观察两组患者病情严重程度、病死率、核酸转化时间、核酸阳性率及临床改善情况。评价不同CCBs对核酸转化的影响。结果:ccb组与对照组的严重程度率差异有统计学意义(63.3% vs. 82.8%, P = 0.038)。CCBs组核酸转化时间明显短于对照组(P = 0.001)。两组间核酸负转化曲线差异有统计学意义(Log Rank P = 0.010), CCBs组优于CCBs组。CCBs组呕吐次数和神经系统症状明显低于对照组(P = 0.049、0.038),血小板水平明显高于对照组(P = 0.015)。硝苯地平组核酸转化率显著高于其他CCBs组(p = 0.036)。结论:我们的研究表明,CCBs可能有助于降低SFTS患者的疾病严重程度,缓解临床症状,并可能减缓病情向严重疾病的发展。
Analysis of the clinical efficacy of CCBs in patients with severe fever with thrombocytopenia syndrome combined with hypertension.
Background: Calcium channel blockers (CCBs), commonly used in the treatment of various cardiovascular diseases, have shown promising potential in inhibiting the formation of viral inclusion bodies by lowering the level of intracellular Ca2+, thereby reducing viral replication. We conducted a retrospective single-center cohort study of SFTS patients with hypertension to assess the impact of CCB therapy on SFTS.
Methods: SFTS patients with hypertension treated in Qishan Hospital of Yantai from May 1, 2018, to December 31, 2022, were included. According to the admission criteria, 94 patients with SFTS were divided into the CCBs group (N = 30) and the control group (patients who took other antihypertensive drugs) (N = 64). We observed the severity of the disease, fatality rate, nucleic acid conversion time, nucleic acid's positive rate, and the clinical improvement of the two groups. The effects of different CCBs on nucleic acid conversion were evaluated.
Results: There was a significant difference in the severity rate between the CCBs and control groups (63.3% vs. 82.8%, P = 0.038). The time of nucleic acid conversion in the CCBs group was significantly shorter than in the control group (P = 0.001). The nucleic acid negative conversion curve differed between the two groups (Log Rank P = 0.010), and the CCBs group was better. The frequency of vomiting and nervous system symptoms in the CCBs group was significantly lower than in the control group (P = 0.049,0.038), and the platelet level was significantly higher in the former than in the latter (P = 0.015). The conversion rate of nucleic acid in patients taking nifedipine was significantly higher than that in patients taking other CCBs (p = 0.036).
Conclusions: Our research indicates that CCBs may aid in decreasing disease severity, easing clinical symptoms, and potentially slowing the advancement to severe illness in patients with SFTS.
期刊介绍:
Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies.
The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.