Patricia A Cioe, Garrett S Stang, Danish Azam, Megan E Piper, Christopher W Kahler
{"title":"吸烟的艾滋病毒感染者预先接受尼古丁替代疗法：一项随机对照试验。","authors":"Patricia A Cioe, Garrett S Stang, Danish Azam, Megan E Piper, Christopher W Kahler","doi":"10.1093/ntr/ntaf123","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Smoking cessation rates in people with HIV (PWH) are lower than in the general population, even when evidence-based treatments are used. This 16-week study examined the feasibility, acceptability, and preliminary efficacy of preloading with nicotine replacement therapy (NRT) in PWH to improve cessation outcomes.</p><p><strong>Methods: </strong>Forty-nine participants were randomized to nicotine patch preloading for 3 weeks (NRT-P) prior to the target quit date (TQD) or standard treatment with no preloading (ST). All participants received combination NRT for 8 weeks at TQD, with five sessions of behavioral counseling. At week 16, biochemically verified 7-day point-prevalence abstinence (PPA) was assessed.</p><p><strong>Results: </strong>Mean preloading patch days was 19.7 (out of 21 days; SD 2.7), indicating excellent acceptability. Mean patch days post-TQD (out of 56 days) was 47.4 (SD = 13.2) in NRT-P and 32.7 (SD = 21.8) in ST (t = -2.48, p=.01). At week 16 there was no group difference in week 16 PPA, but NRT-P participants smoked significantly fewer cigarettes per week (10.1 [SD 14.7] vs. 47.2 [SD 67.6]) and had lower CO levels (5.22 [SD 3.6] vs. 10.89 [SD 11.3], p=.04) compared to ST participants. Cessation self-efficacy increased significantly over time in the NRT-P condition only.</p><p><strong>Conclusions: </strong>NRT preloading is feasible and acceptable among PWH, with excellent adherence to preloading, and benefits observed relative to ST following TQD in patch adherence, self-efficacy, cigarettes smoked per day, and CO levels. The lack of effect of preloading on smoking abstinence suggests further study is needed.</p><p><strong>Implications: </strong>Preloading with nicotine patch among people with HIV (PWH) who smoke prior to the target quit date may be an effective means of improving adherence to smoking cessation medications both pre- and post-quit. By increasing self-efficacy for quitting and lowering cigarette dependence, preloading may improve cessation rates and help reduce the burden of tobacco-related disease among PWH. Further research is needed.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Preloading with nicotine replacement therapy in people with HIV who smoke: a pilot randomized controlled trial.\",\"authors\":\"Patricia A Cioe, Garrett S Stang, Danish Azam, Megan E Piper, Christopher W Kahler\",\"doi\":\"10.1093/ntr/ntaf123\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Smoking cessation rates in people with HIV (PWH) are lower than in the general population, even when evidence-based treatments are used. This 16-week study examined the feasibility, acceptability, and preliminary efficacy of preloading with nicotine replacement therapy (NRT) in PWH to improve cessation outcomes.</p><p><strong>Methods: </strong>Forty-nine participants were randomized to nicotine patch preloading for 3 weeks (NRT-P) prior to the target quit date (TQD) or standard treatment with no preloading (ST). All participants received combination NRT for 8 weeks at TQD, with five sessions of behavioral counseling. At week 16, biochemically verified 7-day point-prevalence abstinence (PPA) was assessed.</p><p><strong>Results: </strong>Mean preloading patch days was 19.7 (out of 21 days; SD 2.7), indicating excellent acceptability. Mean patch days post-TQD (out of 56 days) was 47.4 (SD = 13.2) in NRT-P and 32.7 (SD = 21.8) in ST (t = -2.48, p=.01). At week 16 there was no group difference in week 16 PPA, but NRT-P participants smoked significantly fewer cigarettes per week (10.1 [SD 14.7] vs. 47.2 [SD 67.6]) and had lower CO levels (5.22 [SD 3.6] vs. 10.89 [SD 11.3], p=.04) compared to ST participants. Cessation self-efficacy increased significantly over time in the NRT-P condition only.</p><p><strong>Conclusions: </strong>NRT preloading is feasible and acceptable among PWH, with excellent adherence to preloading, and benefits observed relative to ST following TQD in patch adherence, self-efficacy, cigarettes smoked per day, and CO levels. The lack of effect of preloading on smoking abstinence suggests further study is needed.</p><p><strong>Implications: </strong>Preloading with nicotine patch among people with HIV (PWH) who smoke prior to the target quit date may be an effective means of improving adherence to smoking cessation medications both pre- and post-quit. By increasing self-efficacy for quitting and lowering cigarette dependence, preloading may improve cessation rates and help reduce the burden of tobacco-related disease among PWH. 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Preloading with nicotine replacement therapy in people with HIV who smoke: a pilot randomized controlled trial.
Introduction: Smoking cessation rates in people with HIV (PWH) are lower than in the general population, even when evidence-based treatments are used. This 16-week study examined the feasibility, acceptability, and preliminary efficacy of preloading with nicotine replacement therapy (NRT) in PWH to improve cessation outcomes.
Methods: Forty-nine participants were randomized to nicotine patch preloading for 3 weeks (NRT-P) prior to the target quit date (TQD) or standard treatment with no preloading (ST). All participants received combination NRT for 8 weeks at TQD, with five sessions of behavioral counseling. At week 16, biochemically verified 7-day point-prevalence abstinence (PPA) was assessed.
Results: Mean preloading patch days was 19.7 (out of 21 days; SD 2.7), indicating excellent acceptability. Mean patch days post-TQD (out of 56 days) was 47.4 (SD = 13.2) in NRT-P and 32.7 (SD = 21.8) in ST (t = -2.48, p=.01). At week 16 there was no group difference in week 16 PPA, but NRT-P participants smoked significantly fewer cigarettes per week (10.1 [SD 14.7] vs. 47.2 [SD 67.6]) and had lower CO levels (5.22 [SD 3.6] vs. 10.89 [SD 11.3], p=.04) compared to ST participants. Cessation self-efficacy increased significantly over time in the NRT-P condition only.
Conclusions: NRT preloading is feasible and acceptable among PWH, with excellent adherence to preloading, and benefits observed relative to ST following TQD in patch adherence, self-efficacy, cigarettes smoked per day, and CO levels. The lack of effect of preloading on smoking abstinence suggests further study is needed.
Implications: Preloading with nicotine patch among people with HIV (PWH) who smoke prior to the target quit date may be an effective means of improving adherence to smoking cessation medications both pre- and post-quit. By increasing self-efficacy for quitting and lowering cigarette dependence, preloading may improve cessation rates and help reduce the burden of tobacco-related disease among PWH. Further research is needed.
期刊介绍：
Nicotine & Tobacco Research is one of the world''s few peer-reviewed journals devoted exclusively to the study of nicotine and tobacco.
It aims to provide a forum for empirical findings, critical reviews, and conceptual papers on the many aspects of nicotine and tobacco, including research from the biobehavioral, neurobiological, molecular biologic, epidemiological, prevention, and treatment arenas.
Along with manuscripts from each of the areas mentioned above, the editors encourage submissions that are integrative in nature and that cross traditional disciplinary boundaries.
The journal is sponsored by the Society for Research on Nicotine and Tobacco (SRNT). It publishes twelve times a year.
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