Mustafa Comoglu, Fatih Acehan, Enes Seyda Sahiner, Huseyin Camli, Zeki Mesut Yalin Kilic, Bulent Odemis, Ihsan Ates
{"title":"紧急ERCP对急性胆管炎并发急性胆石性胰腺炎临床结局的影响：倾向评分匹配分析","authors":"Mustafa Comoglu, Fatih Acehan, Enes Seyda Sahiner, Huseyin Camli, Zeki Mesut Yalin Kilic, Bulent Odemis, Ihsan Ates","doi":"10.1002/jhbp.12164","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/purpose: </strong>Current guidelines do not provide specific recommendations regarding the timing of endoscopic retrograde cholangiopancreatography (ERCP) in patients with acute cholangitis (AC) concurrent with acute gallstone pancreatitis (AGP). This study evaluated the impact of ERCP timing on clinical outcomes.</p><p><strong>Methods: </strong>A total of 144 patients diagnosed with AC concurrent with AGP between March 2019 and February 2024 were included in the study. Patients were classified into two groups: urgent ERCP group (ERCP ≤ 24 h) and non-urgent ERCP group (ERCP 24-72 h). Clinical outcomes were compared using propensity score matching (PSM) analysis.</p><p><strong>Results: </strong>After PSM, two well-balanced groups of 55 patients were created. The median ERCP time was 18 (13-21) hours in the urgent group and 41 (36-54) hours in the non-urgent group. There was no significant difference in composite outcomes, including in-hospital mortality, prolonged hospital stay, severe pancreatitis, or late localized/systemic complications of pancreatitis [11 (20%) vs. 16 (29.1%); p = 0.268]. Additionally, no significant difference was observed between the groups regarding prolonged hospital stay (p = 0.506), ICU admission (p = 0.680), or in-hospital mortality (p = 0.161).</p><p><strong>Conclusions: </strong>Urgent ERCP within 24 h does not significantly improve clinical outcomes compared to ERCP performed within 24-72 h in patients with AC and AGP.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2000,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of Urgent ERCP on Clinical Outcomes in Acute Cholangitis With Concurrent Acute Gallstone Pancreatitis: A Propensity Score Matching Analysis.\",\"authors\":\"Mustafa Comoglu, Fatih Acehan, Enes Seyda Sahiner, Huseyin Camli, Zeki Mesut Yalin Kilic, Bulent Odemis, Ihsan Ates\",\"doi\":\"10.1002/jhbp.12164\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background/purpose: </strong>Current guidelines do not provide specific recommendations regarding the timing of endoscopic retrograde cholangiopancreatography (ERCP) in patients with acute cholangitis (AC) concurrent with acute gallstone pancreatitis (AGP). This study evaluated the impact of ERCP timing on clinical outcomes.</p><p><strong>Methods: </strong>A total of 144 patients diagnosed with AC concurrent with AGP between March 2019 and February 2024 were included in the study. Patients were classified into two groups: urgent ERCP group (ERCP ≤ 24 h) and non-urgent ERCP group (ERCP 24-72 h). Clinical outcomes were compared using propensity score matching (PSM) analysis.</p><p><strong>Results: </strong>After PSM, two well-balanced groups of 55 patients were created. The median ERCP time was 18 (13-21) hours in the urgent group and 41 (36-54) hours in the non-urgent group. There was no significant difference in composite outcomes, including in-hospital mortality, prolonged hospital stay, severe pancreatitis, or late localized/systemic complications of pancreatitis [11 (20%) vs. 16 (29.1%); p = 0.268]. Additionally, no significant difference was observed between the groups regarding prolonged hospital stay (p = 0.506), ICU admission (p = 0.680), or in-hospital mortality (p = 0.161).</p><p><strong>Conclusions: </strong>Urgent ERCP within 24 h does not significantly improve clinical outcomes compared to ERCP performed within 24-72 h in patients with AC and AGP.</p>\",\"PeriodicalId\":16056,\"journal\":{\"name\":\"Journal of Hepato‐Biliary‐Pancreatic Sciences\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-06-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Hepato‐Biliary‐Pancreatic Sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/jhbp.12164\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Hepato‐Biliary‐Pancreatic Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jhbp.12164","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
Effect of Urgent ERCP on Clinical Outcomes in Acute Cholangitis With Concurrent Acute Gallstone Pancreatitis: A Propensity Score Matching Analysis.
Background/purpose: Current guidelines do not provide specific recommendations regarding the timing of endoscopic retrograde cholangiopancreatography (ERCP) in patients with acute cholangitis (AC) concurrent with acute gallstone pancreatitis (AGP). This study evaluated the impact of ERCP timing on clinical outcomes.
Methods: A total of 144 patients diagnosed with AC concurrent with AGP between March 2019 and February 2024 were included in the study. Patients were classified into two groups: urgent ERCP group (ERCP ≤ 24 h) and non-urgent ERCP group (ERCP 24-72 h). Clinical outcomes were compared using propensity score matching (PSM) analysis.
Results: After PSM, two well-balanced groups of 55 patients were created. The median ERCP time was 18 (13-21) hours in the urgent group and 41 (36-54) hours in the non-urgent group. There was no significant difference in composite outcomes, including in-hospital mortality, prolonged hospital stay, severe pancreatitis, or late localized/systemic complications of pancreatitis [11 (20%) vs. 16 (29.1%); p = 0.268]. Additionally, no significant difference was observed between the groups regarding prolonged hospital stay (p = 0.506), ICU admission (p = 0.680), or in-hospital mortality (p = 0.161).
Conclusions: Urgent ERCP within 24 h does not significantly improve clinical outcomes compared to ERCP performed within 24-72 h in patients with AC and AGP.
期刊介绍：
The Journal of Hepato-Biliary-Pancreatic Sciences (JHBPS) is the leading peer-reviewed journal in the field of hepato-biliary-pancreatic sciences. JHBPS publishes articles dealing with clinical research as well as translational research on all aspects of this field. Coverage includes Original Article, Review Article, Images of Interest, Rapid Communication and an announcement section. Letters to the Editor and comments on the journal’s policies or content are also included. JHBPS welcomes submissions from surgeons, physicians, endoscopists, radiologists, oncologists, and pathologists.
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