通过比较肿瘤学推进溶瘤病毒治疗的兽医模型的见解。

IF 3.9 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Frontiers in Molecular Biosciences Pub Date : 2025-05-22 eCollection Date: 2025-01-01 DOI:10.3389/fmolb.2025.1615393

Almohanad A Alkayyal

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引用次数: 0

摘要

癌症是一种影响人类和动物的复杂疾病。比较免疫肿瘤学探索跨物种的免疫反应，以开发有效的癌症治疗方法。溶瘤病毒（OVs）作为直接的肿瘤裂解剂和免疫刺激剂，使其成为一种有吸引力的治疗选择。这篇综述强调了自然发生的肿瘤在基于ov的癌症免疫治疗动物模型中的作用。我们研究了不同物种的免疫反应，OV治疗的最新进展，以及精准医学在兽医肿瘤学中的作用。了解这些比较方面可以提高OV在兽医和人类肿瘤学中从临床前到临床应用的转化。

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Insights from veterinary models for advancing oncolytic virotherapy through comparative oncology.

Cancer is a complex disease affecting both humans and animals. Comparative immuno-oncology explores immune responses across species to develop effective cancer therapies. Oncolytic viruses (OVs) serve as both direct tumor-lysing agents and immune stimulants, making them an attractive therapeutic option. This review highlights the role of naturally occurring tumors in animal models for OV-based cancer immunotherapy. We examine immune responses in different species, the latest advancements in OV therapy, and the role of precision medicine in veterinary oncology. Understanding these comparative aspects enhances OV translation from preclinical to clinical applications in both veterinary and human oncology.

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来源期刊

Frontiers in Molecular Biosciences Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

7.20

自引率

4.00%

发文量

1361

审稿时长

14 weeks

期刊介绍： Much of contemporary investigation in the life sciences is devoted to the molecular-scale understanding of the relationships between genes and the environment — in particular, dynamic alterations in the levels, modifications, and interactions of cellular effectors, including proteins. Frontiers in Molecular Biosciences offers an international publication platform for basic as well as applied research; we encourage contributions spanning both established and emerging areas of biology. To this end, the journal draws from empirical disciplines such as structural biology, enzymology, biochemistry, and biophysics, capitalizing as well on the technological advancements that have enabled metabolomics and proteomics measurements in massively parallel throughput, and the development of robust and innovative computational biology strategies. We also recognize influences from medicine and technology, welcoming studies in molecular genetics, molecular diagnostics and therapeutics, and nanotechnology. Our ultimate objective is the comprehensive illustration of the molecular mechanisms regulating proteins, nucleic acids, carbohydrates, lipids, and small metabolites in organisms across all branches of life. In addition to interesting new findings, techniques, and applications, Frontiers in Molecular Biosciences will consider new testable hypotheses to inspire different perspectives and stimulate scientific dialogue. The integration of in silico, in vitro, and in vivo approaches will benefit endeavors across all domains of the life sciences.