木霉醇A - C：三种来自灵芝内生真菌木霉sp. GLQ02的新代谢产物及其抗炎活性。

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-06-03 DOI:10.1016/j.fitote.2025.106657

Ping-Ping Wu , Xin-Huan Qiu , Hua-Jin Yu , Long-Jun Li , Xia Cheng , Yi-Ping Chen , Qi Luo

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引用次数: 0

摘要

从一株源自灵气的内生真菌Trichodermanols A - C（1-3）中分离并鉴定出一种罕见的非甾体(1)和两种新的5/7环系统倍半萜（2和3），以及两种已知化合物(1S,7R,10S,11R)-3-oxoguai-4-ene-11,12-diol(4)和cyclo-(S)- pro -(R)- leu(5)。根据光谱数据和ECD和DP4+计算，对它们的化学结构进行了分析。新分离物1-3在lps刺激的RAW 264.7细胞中进行了生物活性评价。结果表明木霉醇A(1)具有潜在的抗炎活性。

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Trichodermanols A−C, three new metabolites from the Ganoderma lucidum-derived endophytic Trichoderma sp. GLQ02 and their anti-inflammatory activity

Trichodermanols A−C (1–3), an uncommon nor-steroid (1) and two novel 5/7 ring system sesquiterpenes (2 and 3), along with two known compounds identified as (1S,7R,10S,11R)-3-oxoguai-4-ene-11,12-diol (4) and cyclo-((S)-Pro-(R)-Leu) (5), were isolated and elucidated from a Ganoderma lucidum-derived endophytic fungus Trichoderma sp. GLQ02. Their chemical structures were elucidated on the basis of spectroscopic data and ECD and DP4⁺ calculations. The biological activity of new isolates 1–3 was evaluated in LPS-stimulated RAW 264.7 cells. The results revealed that trichodermanol A (1) exhibited potential anti-inflammatory activity.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.

木霉醇A - C：三种来自灵芝内生真菌木霉sp. GLQ02的新代谢产物及其抗炎活性。

摘要

木霉醇A - C：三种来自灵芝内生真菌木霉sp. GLQ02的新代谢产物及其抗炎活性。