预防和治疗性EBV疫苗接种。

3区医学 Q2 Medicine

Current topics in microbiology and immunology Pub Date : 2025-06-07 DOI:10.1007/82_2025_308

Rajiv Khanna, Jeffrey I Cohen

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引用次数: 0

摘要

Epstein-Barr病毒（EBV）疫苗可以预防原发性感染和EBV直接引起的疾病，包括单核细胞增多症和移植后淋巴细胞增生性疾病。预防性疫苗也可能预防或减少以EBV为辅助因子的疾病，包括多发性硬化症和其他自身免疫性疾病、EBV阳性B细胞淋巴瘤、鼻咽癌和某些胃癌。另外，EBV疫苗可用于治疗与EBV相关的自身免疫性疾病和恶性肿瘤。一般来说，预防性疫苗侧重于诱导病毒抗体，而治疗性疫苗侧重于诱导病毒特异性T细胞杀死或控制病毒感染的细胞。

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Prophylactic and Therapeutic EBV Vaccination.

Vaccines for Epstein-Barr virus (EBV) could be prophylactic to prevent primary infection and diseases directly caused by EBV, including mononucleosis and posttransplant lymphoproliferative disease. Prophylactic vaccines might also prevent or reduce diseases in which EBV is a cofactor, including multiple sclerosis and other autoimmune disorders, EBV-positive B cell lymphomas, nasopharyngeal carcinoma, and certain gastric carcinomas. Alternatively, EBV vaccines could be therapeutic to treat autoimmune disease and malignancies associated with EBV. In general, prophylactic vaccines focus on induction of antibody to the virus, while therapeutic vaccines focus on inducing virus-specific T cells to kill or control virus-infected cells.

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来源期刊

Current topics in microbiology and immunology 医学-免疫学

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The review series Current Topics in Microbiology and Immunology provides a synthesis of the latest research findings in the areas of molecular immunology, bacteriology and virology. Each timely volume contains a wealth of information on the featured subject. This review series is designed to provide access to up-to-date, often previously unpublished information.