两种早期描述的东耐巴豆叶黄酮苷及其乙酰胆碱酯酶抑制活性。

IF 2.3 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2025-06-05 DOI:10.1002/cbdv.202501463

Nguyen Thi Kim Thuy, Nguyen Duc Duy, Nguyen Thi Hanh, Nguyen Quang Huy, Nguyen Van Huan, Quan Cam Thuy, Bui Huu Tai, Phan Van Kiem

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引用次数: 0

摘要

从冬瓜叶中分离得到2个未描述的黄烷醇苷（1和2）和10个已知的酚类化合物（3 ~ 12）。用高分辨率电喷雾质谱和核磁共振谱测定了它们的化学结构。化合物1和2的绝对构型用电子圆二色性光谱进行了表征。化合物1 ~ 12表现出较弱的乙酰胆碱酯酶抑制活性，IC50值为72.31±2.14 ~ 251.24±6.18µM。

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Two Earlier Undescribed Flavanone Glycosides From the Leaves of Croton dongnaiensis With Their Acetylcholinesterase Inhibitory Activity.

Two undescribed flavanol glycosides (1 and 2), together with 10 known phenolic compounds (3-12) were isolated from the leaves of Croton dongnaiensis. Their chemical structures were determined by high-resolution electrospray ionization mass spectrometry and nuclear magnetic resonance spectra. The absolute configuration of compounds 1 and 2 were elucidated by electronic circular dichroism spectra. Compounds 1-12 showed weak acetylcholinesterase inhibitory activity with IC₅₀ values ranging from 72.31 ± 2.14 to 251.24 ± 6.18 µM.

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.