酒精相关性肝病患者骨基质矿化、显微硬度和矿化骨细胞腔隙密度的位点特异性改变:对椎体骨折倾向的影响

IF 5.9 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Jelena Jadzic, Christine Plumeyer, Danica Djukic, Vladimir Zivkovic, Slobodan Nikolic, Annegreet Vlug, Nada Tomanovic, Marija Djuric, Petar Milovanovic, Björn Busse, Danijela Djonic
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引用次数: 0

摘要

据报道,低骨质量是酒精相关性肝病(AALD)患者骨脆性的一个来源。骨基质的改变,包括空间骨矿物质密度分布和骨细胞腔隙网络特征,尚未在AALD患者的常见骨折部位得到全面评估。考虑到这些个体椎体和股骨脆性骨折的临床相关性,本横断面研究旨在分析成年男性AALD患者第一腰椎和股骨上外侧颈的部位特异性骨密度分布、骨力学特性、骨细胞腔隙网络和哈弗斯系统特征。采用定量背散射电子成像和维克斯显微压痕试验对成年男性供体尸检采集的椎体和股骨标本(n = 24)进行骨质量分析,分为2组:AALD组(经组织病理学证实为AALD的12例,年龄60±12岁)和年龄匹配的对照组(12例无肝脏疾病的组织病理学特征,年龄59±12岁)。对比评估显示,从AALD组获得的平均钙含量显著降低,维氏显微硬度降低,矿化物质(即微岩石症)闭塞的骨细胞腔隙密度更高,骨壁更厚,腰椎和股骨上外侧颈的骨细胞再填充百分比更高(p
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Site-specific alterations of bone matrix mineralization, micro-hardness, and density of mineralized osteocyte lacunae in men with alcohol-associated liver disease: implications for vertebral fracture predilection.

Low bone quality has been reported as a source of bone fragility in individuals with alcohol-associated liver disease (AALD). Alterations of the bone matrix, including the spatial BMD distribution and osteocyte lacunar network characteristics, have not been comprehensively assessed in common fracture sites of individuals with AALD. Considering the clinical relevance of vertebral and femoral fragility fractures among these individuals, this cross-sectional study aimed to analyze site-specific BMD distribution, bone mechanical properties, osteocyte lacunar network, and Haversian system characteristics in the first lumbar vertebra and superolateral femoral neck of adult male donors with AALD. Quantitative backscattered electron imaging and Vickers micro-indentation testing were conducted to analyze bone quality in specimens from vertebral and femoral bone harvested at autopsy from adult male donors (n = 24), divided into 2 groups: AALD group (12 individuals with histopathological confirmation of AALD, age: 60 ± 12 yr) and age-matched controls (12 individuals without histopathological features of liver disease, age: 59 ± 12 yr). The comparative assessment revealed significantly lower mean calcium content, reduced Vickers micro-hardness, higher density of osteocyte lacunae occluded with mineralized matter (ie, micropetrosis), thicker osteonal wall, and a higher percentage of osteon refilling in lumbar vertebrae and superolateral femoral neck obtained from the AALD group (p < .05). Although bone quality alterations were congruent in both skeletal sites, the most severe AALD-induced impairment was noted in the trabecular compartment of lumbar vertebrae (p < .05). Our findings revealed a site-specific reduction in trabecular bone mineralization and an increased proportion of mineralized osteocyte lacunae in male individuals with AALD, which may contribute to increased vertebral predilection in these individuals.

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来源期刊
Journal of Bone and Mineral Research
Journal of Bone and Mineral Research 医学-内分泌学与代谢
CiteScore
11.30
自引率
6.50%
发文量
257
审稿时长
2 months
期刊介绍: The Journal of Bone and Mineral Research (JBMR) publishes highly impactful original manuscripts, reviews, and special articles on basic, translational and clinical investigations relevant to the musculoskeletal system and mineral metabolism. Specifically, the journal is interested in original research on the biology and physiology of skeletal tissues, interdisciplinary research spanning the musculoskeletal and other systems, including but not limited to immunology, hematology, energy metabolism, cancer biology, and neurology, and systems biology topics using large scale “-omics” approaches. The journal welcomes clinical research on the pathophysiology, treatment and prevention of osteoporosis and fractures, as well as sarcopenia, disorders of bone and mineral metabolism, and rare or genetically determined bone diseases.
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