Shiqi Wang, Jiaqing Guo, Yixuan Yang, Ping Lu, Zhaoyuan Zhang, Shijun Huang, Ye Fang, Hui Zhang, Han Zhang, Wenhui Yu, Junle Qu, Liwei Liu
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Visual Diagnostic Strategy for Assessing the Impact of Aerobic Glycolytic Processes on Tumor Growth and Therapy.
Investigating the role of nicotinamide phosphoribosyltransferase (NAMPT) in tumor growth is significant for enhancing cancer treatment outcomes. This work proposes fluorescence lifetime endoscopic microscopy (FLIME) for the real-time visualization of aerobic glycolysis in the tumor microenvironment. We investigated the effect of NAMPT inhibition using the FK866 small-molecule inhibitor in a mouse model. The results show that FK866 effectively inhibits the NAD+-induced aerobic glycolysis process and decelerates tumor growth. Moreover, the combined effect of FK866 with cisplatin can further inhibit tumor proliferation and progression. These findings indicate that the acidity of the tumor microenvironment can serve as a metric for evaluating the extent of aerobic glycolysis and its implications for tumor growth and treatment, offering a potentially valuable approach for assessing clinical drug efficacy.
期刊介绍：
Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including:
- Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale
- Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies
- Modeling and simulation of synthetic, assembly, and interaction processes
- Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance
- Applications of nanoscale materials in living and environmental systems
Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.
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