免疫系统的神经调节：脑导向免疫治疗的意义

IF 6.6 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2025-06-06 DOI:10.1016/j.coi.2025.102568

Daniel H Cho , Jun R Huh , Gloria B Choi

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引用次数: 0

摘要

免疫系统曾经被认为对大脑的影响有限，现在被认为是大脑和行为的有力调节剂。这篇综述探讨了对脑免疫轴的不断发展的理解，突出了免疫细胞和分子在神经调节和行为调节中的作用，重点介绍了最近的研究结果，详细介绍了免疫因子如白细胞介素(IL)-17A、IL- 17e、IL-4、C-C基序趋化因子配体5和基质金属蛋白酶8对社会行为、学习、记忆和应激易感性的影响。免疫疗法的出现彻底改变了癌症和自身免疫性疾病的治疗方法。新出现的证据表明，类似的方法可以通过靶向失调的脑免疫相互作用来治疗神经和精神疾病。深入了解大脑和免疫系统之间的复杂关系，对于释放免疫调节对大脑疾病的治疗潜力以及将免疫系统定位为恢复精神健康的关键角色至关重要。

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Neuromodulation by the immune system: implications for brain-directed immunotherapy

Once believed to be limited in its impact on the brain, the immune system is now recognized as a potent modulator of the brain and behavior. This review explores the evolving understanding of the brain–immune axis, highlighting the role of immune cells and molecules in neuromodulation and behavioral regulation, with a focus on recent findings detailing the influence of immune factors like interleukin (IL)-17A, IL-17E, IL-4, C-C motif chemokine ligand 5, and matrix metalloproteinase 8 on social behavior, learning, memory, and stress susceptibility. The advent of immunotherapy has revolutionized treatments for cancer and autoimmune diseases. Emerging evidence suggests that similar approaches could address neurological and psychiatric disorders by targeting dysregulated brain–immune interactions. A deeper understanding of the complex relationship between the brain and the immune system will be essential for unlocking the therapeutic potential of immunomodulation for brain disorders and positioning the immune system as a key player in restoring mental health.

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.