特定氨基酸的营养感知和信号传导：来自果蝇研究的见解

IF 4.3 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2025-06-07 DOI:10.1016/j.ceb.2025.102547

Ayano Oi , Fumiaki Obata

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引用次数: 0

摘要

维持氨基酸（AA）的稳态对生物体是必要的。为了实现这一目标，生物体进化出各种信号通路，通过感知一般或特定的AA水平来调节。最近，遗传和饮食控制方面的进展揭示了这些AA信号通路如何调节生物体生理、代谢、行为和寿命。然而，阐明每个AA被感知和影响动物生活的详细机制是具有挑战性的。在一些模式生物中，如黑腹果蝇，化学定义的饮食已经发展到控制单一营养素，这使我们能够研究对特定AAs的饮食限制的有机体反应。在这篇综述中，我们旨在讨论动物对膳食氨基酸反应的最新发现，重点介绍了果蝇的最新研究。

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Nutrient sensing and signalling of specific amino acids: Insights from Drosophila study

Maintaining amino acid (AA) homeostasis is necessary for organisms. To achieve this, organisms have evolved various signalling pathways regulated by sensing general or specific AA levels. Recently, advances in genetic and dietary manipulation have shed light upon how these AA signalling pathways regulate organismal physiology, metabolism, behaviour, and lifespan. However, elucidating the detailed mechanisms by which each AA is sensed and influences an animal's life is challenging. In some model organisms such as Drosophila melanogaster, chemically defined diet has been developed to manipulate single nutrients, which enables us to study the organismal response to dietary restriction of particular AAs. In this review, we aim to discuss the latest findings on animals' responses to dietary AAs, with a focus on recent studies in Drosophila.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.