{"title":"胰腺混合性神经内分泌非神经内分泌细胞瘤2例，具有明显的分子病理特征。","authors":"Satomi Saito, Yukiko Takayama, Mariko Tanaka, Nao Otsuka, Junichi Akao, Junko Tahara, Masataka Kikuyama, Katsutoshi Tokushige, Taito Itoh, Toru Furukawa, Ryota Higuchi, Takehisa Yazawa, Kyoko Shimizu","doi":"10.2169/internalmedicine.5083-24","DOIUrl":null,"url":null,"abstract":"<p><p>We herein report two cases of pancreatic mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs). Case A was a mixed ductal-neuroendocrine cell carcinoma with a KRAS mutation and loss of RB1 and SMAD4 expression. Case B was a mixed acinar-neuroendocrine cell carcinoma with wild-type KRAS and loss of p16 and SMAD4 expression. The expression of RB1 and ARID1A was also reduced. These results support the recently proposed classification of neuroendocrine carcinoma into ductal and acinar types based on molecular features, which may facilitate the understanding and development of specific treatments for this intractable tumor.</p>","PeriodicalId":520650,"journal":{"name":"Internal medicine (Tokyo, Japan)","volume":" ","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Two Cases of Mixed Neuroendocrine Non-neuroendcrine Cell Neoplasms (MiNENs) of the Pancreas with Notable Molecular Pathological Features.\",\"authors\":\"Satomi Saito, Yukiko Takayama, Mariko Tanaka, Nao Otsuka, Junichi Akao, Junko Tahara, Masataka Kikuyama, Katsutoshi Tokushige, Taito Itoh, Toru Furukawa, Ryota Higuchi, Takehisa Yazawa, Kyoko Shimizu\",\"doi\":\"10.2169/internalmedicine.5083-24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We herein report two cases of pancreatic mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs). Case A was a mixed ductal-neuroendocrine cell carcinoma with a KRAS mutation and loss of RB1 and SMAD4 expression. Case B was a mixed acinar-neuroendocrine cell carcinoma with wild-type KRAS and loss of p16 and SMAD4 expression. The expression of RB1 and ARID1A was also reduced. These results support the recently proposed classification of neuroendocrine carcinoma into ductal and acinar types based on molecular features, which may facilitate the understanding and development of specific treatments for this intractable tumor.</p>\",\"PeriodicalId\":520650,\"journal\":{\"name\":\"Internal medicine (Tokyo, Japan)\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-06-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Internal medicine (Tokyo, Japan)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2169/internalmedicine.5083-24\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Internal medicine (Tokyo, Japan)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2169/internalmedicine.5083-24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Two Cases of Mixed Neuroendocrine Non-neuroendcrine Cell Neoplasms (MiNENs) of the Pancreas with Notable Molecular Pathological Features.
We herein report two cases of pancreatic mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs). Case A was a mixed ductal-neuroendocrine cell carcinoma with a KRAS mutation and loss of RB1 and SMAD4 expression. Case B was a mixed acinar-neuroendocrine cell carcinoma with wild-type KRAS and loss of p16 and SMAD4 expression. The expression of RB1 and ARID1A was also reduced. These results support the recently proposed classification of neuroendocrine carcinoma into ductal and acinar types based on molecular features, which may facilitate the understanding and development of specific treatments for this intractable tumor.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
