高血压患者肱动脉血流介导扩张(FMD)的内皮功能。

IF 1.9
Elaine Alves Santos Tessier, Carla Daltro, Eduardo Martins Netto, Glauco Moniz de Aragão Doria, Andrea Jimena Gutierrez Peredo, Fabio Bulhões, Roque Aras, Ryan A Harris
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引用次数: 0

摘要

背景:传统上,高血压(BP)值与缺血性心脏病、中风、慢性肾脏疾病和早期死亡的风险相关。袖带收缩后的肱动脉FMD已成为量化内皮功能的标准参数,由于其无创性、与冠状动脉内皮功能密切相关以及与长期冠状动脉事件发生率相关,成为一种有用的替代结果。目的:检验FMD与一些血液参数之间相关性的假设,比较FMD改变组和未改变组之间的参数,以及顽固性高血压组(RHTN和非RHTN)高血压患者之间的参数。方法:来自转诊高血压门诊的72名志愿者参与了这项前瞻性横断面研究,其中比较了FMD改变组(n = 38)和FMD未改变组(n = 34)以及RHTN (n = 49)和非RHTN (n = 23)组之间的一些患者变量。本研究还调查了解释口蹄疫的变量。当假设满足时,采用参数方法进行统计分析,否则采用非参数方法。统计学分析采用显著性水平5%。结果:FMD与LDL呈显著正相关(p = 0.204, p = 0.042),与甘油三酯呈显著正相关(p = 0.247, p = 0.037)。RHTN组糖化血红蛋白升高(p = 0.020),非RHTN组钾离子升高(p = 0.029), RHTN组c反应蛋白升高(p = 0.04)。对于其他比较,没有发现统计学上的显著差异。结论:低密度脂蛋白和甘油三酯是FMD的预测因子,RHTN组和非RHTN组在钾、蛋白C和糖化血红蛋白的含量方面存在差异。改变和未改变的FMD组仅在甘油三酯方面有所不同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Endothelial Function by Flow-Mediated Dilation (FMD) in the Brachial Artery in Hypertensive Patients.

Background: High blood pressure (BP) values have traditionally been associated with the risk of ischemic heart disease, stroke, chronic kidney disease, and early mortality. The brachial artery FMD after cuff deflation has become the standard parameter for quantifying endothelial function, being a useful surrogate outcome due to its non-invasiveness, close correlation with coronary endothelial function, and association with the incidence of long-term coronary events.

Objectives: To test hypotheses of correlation between the FMD and several blood parameters and to compare parameters between altered and non-altered FMD groups, and between hypertensive patients in the resistant hypertension groups (RHTN and non-RHTN).

Methods: Seventy-two volunteers from a referral hypertension outpatient clinic participated in this prospective cross-sectional study, in which several patient variables were compared between the altered FMD (n = 38) and non-altered FMD (n = 34) groups, and also between the RHTN (n = 49) and non-RHTN (n = 23) groups. The variables that would explain the FMD were also investigated in this study. Statistical analyses were performed using parametric methods when the assumptions were met, and non-parametric methods otherwise. The significance level adopted in the statistical analysis was 5%.

Results: The results showed a significant positive correlation between the FMD and LDL (p = 0.204, p = 0.042) and between FMD and triglycerides (p = 0.247, p = 0.037). Glycated hemoglobin was higher in the RHTN group (p = 0.020), potassium was higher in the non-RHTN group (p = 0.029), and C-reactive protein was higher in the RHTN group (p = 0.04). For the other comparisons, no statistically significant differences were found.

Conclusion: LDL and triglycerides are FMD predictors, and the RHTN and non-RHTN groups differ in terms of the amount of potassium, protein C, and glycated hemoglobin. The altered and non-altered FMD groups differ only in terms of triglycerides.

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