调查黄热病疫苗接种与有症状的急性寨卡病毒感染之间的关系:一项病例对照研究。

IF 2.3 4区 医学 Q2 PARASITOLOGY
Lisany Krug Mareto, Sahra de Almdeira Metzker, Camila Guadeluppe Maciel, Bruna Luiza de Amorin Vilharba, Fabio Antonio Venancio, Wagner de Souza Fernandes, Cláudia Du Bocage Santos-Pinto, Everton Falcão de Oliveira
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引用次数: 0

摘要

背景:在拉丁美洲寨卡病毒(ZIKV)流行期间(2015-2016年),在黄热病(YF)疫苗接种覆盖率低的地方观察到小头症的高发。寨卡病毒和YF病毒之间的交叉反应被假设为可能的解释。方法:我们采用病例对照研究,根据患者接种YF的情况估计寨卡病毒感染的几率。该研究将寨卡病毒热视为结果,将之前接种的黄热病疫苗视为暴露。我们纳入了2015年1月至2018年12月在南马托格罗索州坎波格兰德发生的所有确诊急性寨卡病毒热病例。对照组由年龄和性别匹配的坎波格兰德居民组成,他们在研究期间没有急性发热虫媒病毒史。结果:寨卡病毒急性热累计发病率为1.87例/ 1000人。病例组以20-39岁的女性、白人和混血儿为主。病例组YF疫苗接种率为65.5%,对照组为60.9%。优势比(OR)表明结果与暴露之间存在弱关联(OR = 1.23;95%置信区间[CI]: 1.05-1.44)。结论:我们的发现没有证据表明事先接种YF疫苗可以预防急性寨卡病毒感染。由于预测新的寨卡病毒流行,需要进一步的研究来分析受感染个体中抗寨卡病毒和抗yf中和抗体的发展情况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigating the association between yellow fever vaccination and symptomatic acute Zika virus infection: a case-control study.

Background: During the Zika virus (ZIKV) epidemic in Latin America (2015-2016), a high incidence of microcephaly was observed in places with low yellow fever (YF) vaccination coverage. Cross-reactivity between ZIKV and YF virus was hypothesized as a possible explanation.

Methods: We performed a case-control study to estimate the odds of ZIKV infection according to patients' YF vaccination status. The study considered ZIKV fever as the outcome, and previous vaccination against YF as exposure. We included all confirmed cases of acute ZIKV fever in Campo Grande, Mato Grosso do Sul, from January 2015 to December 2018. The control group comprised age- and sex-matched residents of Campo Grande who had no history of acute febrile arboviruses during the study period.

Results: The cumulative incidence of acute ZIKV fever was 1.87 cases per 1000 population. The case group had a predominance of women aged 20-39 years and white and mixed races. Vaccination coverage for YF was 65.5% in the case group and 60.9% in the control group. The odds ratio (OR) suggested a weak association between outcomes and exposure (OR = 1.23; 95% confidence interval [CI]: 1.05-1.44).

Conclusions: Our findings provide no evidence that prior YF vaccination protects against acute ZIKV infection. Further studies are needed to analyze the development of anti-ZIKV and anti-YF neutralizing antibodies in affected individuals because new ZIKV epidemics are predicted.

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来源期刊
CiteScore
3.40
自引率
10.00%
发文量
195
审稿时长
3-8 weeks
期刊介绍: The Journal of the Brazilian Society of Tropical Medicine (JBSTM) isan official journal of the Brazilian Society of Tropical Medicine) with open access. It is amultidisciplinary journal that publishes original researches related totropical diseases, preventive medicine, public health, infectious diseasesand related matters. Preference for publication will be given to articlesreporting original observations or researches. The journal has a peer-reviewsystem for articles acceptance and its periodicity is bimonthly. The Journalof the Brazilian Society of Tropical Medicine is published in English.The journal invites to publication Major Articles, Editorials, Reviewand Mini-Review Articles, Short Communications, Case Reports, TechnicalReports, Images in Infectious Diseases, Letters, Supplements and Obituaries.
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