B细胞的表观遗传机制：SLE靶向治疗的最新进展。

IF 1.9 4区医学 Q3 RHEUMATOLOGY

Lupus Pub Date : 2025-06-04 DOI:10.1177/09612033251348154

Kunyu Cao, Xiaoping Du, Miao Tu, Yujiao Wei, Liu Wan, Jiyu Ju

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引用次数: 0

摘要

系统性红斑狼疮（SLE）是一种复杂的自身免疫性疾病，b细胞功能异常在其发病机制中起关键作用。多种表观遗传机制，如DNA甲基化、组蛋白修饰和非编码rna，可以调节B细胞的发育、分化和功能。本文综述了B细胞的表观遗传调控与SLE发病机制之间的关系，并对可能的治疗方法进行了展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Epigenetic mechanisms of B cells: Recent advances in targeted therapies for SLE.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease, and abnormal B-cell function plays a key role in its pathogenesis. Multiple epigenetic mechanisms, such as DNA methylation, histone modification, and non-coding RNAs, can regulate B cell development, differentiation, and function. This review outlines the relationship between the epigenetic regulation of B cells and the pathogenesis of SLE and prospectively discusses possible therapeutic approaches.

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来源期刊

Lupus 医学-风湿病学

CiteScore

4.20

自引率

11.50%

发文量

225

审稿时长

1 months

期刊介绍： The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…