血铅与心血管疾病发病率和死亡率的关系:来自强心脏研究队列的发现

IF 10.1 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Wil Lieberman-Cribbin, Anne E Nigra, Allison Kupsco, Arce Domingo-Relloso, Kathrin Schilling, Ying Zhang, Amanda M Fretts, Shelley Cole, Jason G Umans, Jeffery M Jarrett, Michael Lewin, Patricia Ruiz, Zheng Li, Ana Navas-Acien
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引用次数: 0

摘要

背景:关于铅和心血管疾病(CVD)负担的证据来自国家健康和营养检查调查(NHANES)数据,这是美国人口的一般样本,缺乏美洲印第安人的充分代表。此外,关于铅和心血管事件结局的前瞻性证据有限。目的:我们评估血铅水平是否与美国印第安成年人心血管疾病死亡率和发病率有关。方法:采用电感耦合血浆质谱法对1998-1999年1818名受试者的全血进行铅含量分析。截至2019年,心血管疾病发病率和死亡率均可获得。我们使用逐步调整的多变量Cox比例风险模型,通过基线血铅水平来估计复合心血管疾病和冠心病(CHD)死亡率和发病率的风险。结果:血铅中位数(p20, p80)为22.5(14.2,37.3)µg/L,与NHANES 1999-2000中美国成年人的代表性样本相似。在随访期间,578名(31.8%)参与者有复合心血管疾病事件,454名(25.0%)参与者有冠心病事件。在调整了人口统计学、生活方式和心血管危险因素后,第80到20分位数血铅每变化的危险比(95% CI)在CVD和CHD死亡率中分别为1.15(1.02-1.30)和1.22(1.08- 1.37),在CVD和CHD发病率中分别为1.13(1.02-1.24)和1.12(0.99-1.25)。在灵活的剂量-反应模型中,这种关联似乎是非线性的,当血铅浓度高于35 μ g/L时,心血管疾病和冠心病死亡风险明显增加。讨论:美国印第安成年人的血铅水平与美国和全球人口相当,与心血管疾病和冠心病发病率和死亡率增加有关。这些发现强调了进一步减少铅暴露的重要性,包括美国印第安人社区。https://doi.org/10.1289/EHP16309。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Association of Blood Lead with Cardiovascular Disease Incidence and Mortality: Findings from the Strong Heart Study Cohort.

Background: Evidence on lead and the burden of cardiovascular disease (CVD) derived from National Health and Nutrition Examination Survey (NHANES) data, a general sample of the U.S. population, lacks sufficient representation of American Indians. Moreover, there is limited prospective evidence on lead and incident CVD outcomes.

Objectives: We evaluated if blood lead levels were associated with CVD mortality and incidence in American Indian adults from the Strong Heart Study (SHS).

Methods: Whole blood samples collected in 1998-1999 among 1,818 participants was analyzed for lead using inductively coupled plasma mass spectrometry. CVD incidence and mortality were available through 2019. We used progressively adjusted multivariable Cox proportional hazards models to estimate the risk of composite CVD and coronary heart disease (CHD) mortality and incidence by baseline blood lead levels.

Results: The median (p20, p80) blood lead was 22.5 (14.2, 37.3) µg/L, similar to that of a representative sample of US adults in NHANES 1999-2000. During follow-up, 578 (31.8%) participants had a composite CVD event and 454 (25.0%) participants had a CHD event. After adjustment for demographic, lifestyle, and cardiovascular risk factors, the hazard ratio (95% CI) per change across the 80th to 20th quantiles in blood lead was 1.15 (1.02-1.30) and 1.22 (1.08- 1.37) for CVD and CHD mortality, respectively, and 1.13 (1.02-1.24) and 1.12 (0.99-1.25) for CVD and CHD incidence, respectively. In flexible dose-response models, the associations appeared to be non-linear, with a clear increased risk of CVD and CHD mortality at blood lead concentrations above 35 µg/L.

Discussion: Blood lead levels in American Indian adults, which are comparable to populations in the U.S. and globally, were associated with increased risk of CVD and CHD incidence and mortality. These findings highlight the importance of further reducing lead exposure, including American Indian communities. https://doi.org/10.1289/EHP16309.

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来源期刊
Environmental Health Perspectives
Environmental Health Perspectives 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
14.40
自引率
2.90%
发文量
388
审稿时长
6 months
期刊介绍: Environmental Health Perspectives (EHP) is a monthly peer-reviewed journal supported by the National Institute of Environmental Health Sciences, part of the National Institutes of Health under the U.S. Department of Health and Human Services. Its mission is to facilitate discussions on the connections between the environment and human health by publishing top-notch research and news. EHP ranks third in Public, Environmental, and Occupational Health, fourth in Toxicology, and fifth in Environmental Sciences.
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