用持续胶原基质脱细胞骨新方案后骨组织中COVID-19的检测

IF 1.4 4区医学 Q4 CELL BIOLOGY

Cell and Tissue Banking Pub Date : 2025-06-05 DOI:10.1007/s10561-025-10178-z

Leticia Ramos Dantas, Felipe Francisco Tuon

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引用次数: 0

摘要

导致COVID-19的SARS-CoV-2病毒在器官和组织捐赠中的传播率尚不清楚。考虑到SARS-CoV-2传播风险和供体排斥导致组织短缺的风险，本体外研究评估了组织库骨处理后骨组织模型中SARS-CoV-2 RNA的检测。骨加工具有抗SARS-CoV-2的活性，但在加工结束时未检测到RNA。在骨组织短缺的情况下，可以考虑使用骨组织。

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COVID-19 detection in bone tissue after a new protocol for decellularize bone with sustained collagen matrix.

The transmissibility rate of the SARS-CoV-2 virus, which causes COVID-19, in organ and tissue donation is not known. Considering all issues related to the risk of SARS-CoV-2 transmission and the risk of tissue shortages due to donor exclusion, this in vitro study evaluated the detection of SARS-CoV-2 RNA in bone tissue models after bone processing for tissue bank. Bone processing has activity against SARS-CoV-2 and not RNA was detected in the end of the process. The use of bone tissue can be considered in case of shortage.

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来源期刊

Cell and Tissue Banking CELL BIOLOGY-ENGINEERING, BIOMEDICAL

CiteScore

3.10

自引率

13.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Cell and Tissue Banking provides a forum for disseminating information to scientists and clinicians involved in the banking and transplantation of cells and tissues. Cell and Tissue Banking is an international, peer-reviewed journal that publishes original papers in the following areas: basic research concerning general aspects of tissue banking such as quality assurance and control of banked cells/tissues, effects of preservation and sterilisation methods on cells/tissues, biotechnology, etc.; clinical applications of banked cells/tissues; standards of practice in procurement, processing, storage and distribution of cells/tissues; ethical issues; medico-legal issues.