溃疡性结肠炎患者英夫利昔单抗诱导的免疫性血小板减少性紫癜。

IF 0.5 Q4 GASTROENTEROLOGY & HEPATOLOGY

Case Reports in Gastroenterology Pub Date : 2025-06-04 eCollection Date: 2025-01-01 DOI:10.1159/000545922

Mark Lai, Timothy Phan, Ola Niewiadomski, Nik Ding

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引用次数: 0

摘要

溃疡性结肠炎是一种影响结肠的慢性炎症性疾病。抗肿瘤坏死因子- α药物是溃疡性结肠炎诱导和维持缓解的基石。血小板减少症是这些药物的罕见副作用。病例介绍：我们提出一个病例英夫利昔单抗诱导的免疫性血小板减少性紫癜在一个34岁的女性溃疡性结肠炎患者。结论：英夫利昔单抗可引起药物性免疫相关性血小板减少症，应定期监测患者血小板计数。对于最近开始使用英夫利昔单抗的严重血小板减少症患者，及时转诊到血液学专业是必要的。

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Infliximab-Induced Immune Thrombocytopenic Purpura in an Ulcerative Colitis Patient.

Introduction: Ulcerative colitis is a chronic inflammatory disease affecting the colon. Anti-tumor necrosis factor-alpha drugs are a cornerstone of management in ulcerative colitis both in induction and maintenance of remission. Thrombocytopenia is a rare side effect of these drugs.

Case presentation: We present a case of infliximab-induced immune thrombocytopenic purpura in a 34-year-old female ulcerative colitis patient.

Conclusion: Infliximab can be a cause of drug-induced immune-related thrombocytopenia and patient's platelet counts should be regularly monitored. In patients with severe thrombocytopenia and having been recently commenced on infliximab, prompt referral to hematology specialty is essential.

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