杏仁核中央的促肾上腺皮质激素释放激素神经元：疼痛、情绪和成瘾神经生物学的综合中枢。

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-06-02 DOI:10.1016/j.brainres.2025.149753

Jia Li , Zi-Ang Li , Hui-Min Tian , Sha-Sha Tao , Qian Zhang , Fei Li , Yun-Qing Li

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引用次数: 0

摘要

中央杏仁核（CeA）是边缘系统中的一个关键节点。CeA内的促肾上腺皮质激素释放激素阳性（CRH+）神经元对调节应激反应和消极情绪行为至关重要。近年来对CeA中CRH+神经元的研究表明，CRH+神经元在疼痛、负面情绪、恐惧记忆和药物戒断等生理调节中具有多方面和重要的生物学作用。本文旨在全面分析CeA内的神经元亚型及其分布、CeA内CRH+神经元的传入和传出连通性及其相关的功能作用，从而为未来的研究提供见解和框架。

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Corticotropin-releasing hormone neurons in the central Amygdala: An integrative hub for pain, emotion, and addiction neurobiology

The central amygdala (CeA) is a critical node within the limbic system. Corticotropin-releasing hormone-positive (CRH⁺) neurons within the CeA are essential for modulating stress responses and negative emotional behaviors. Recent investigations on CRH⁺ neurons in CeA have elucidated their multifaceted and significant biological roles in physiological regulation, encompassing pain, negative emotion, fear memory, and drug withdrawal. This review seeks to provide a comprehensive analysis of the neuronal subtypes and their distribution within the CeA, the afferent and efferent connectivity of of CRH⁺ neurons in the CeA, and their associated functional roles, thereby providing insights and a framework for future research.

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.