啮齿动物焦虑和感觉运动解体的Suok“绳索行走”测试：А其在神经科学研究中的应用20年总结。

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research Pub Date : 2025-06-02 DOI:10.1016/j.bbr.2025.115677

Vyacheslav D. Riga , Alisa E. Makhortykh , David S. Galstyan , Murilo S. de Abreu , Allan V. Kalueff

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引用次数: 0

摘要

Suok（钢丝绳行走）测试于2004年开发，用于同时评估啮齿动物的运动活动、焦虑样行为、感觉运动解体及其相互作用。在过去的20年里，这种“混合”测试已被全球各实验室用于大鼠和小鼠神经行为研究。在这里，我们详细介绍了Suok测试，它的过去和现在的用途，方法的优势和局限性，以及存在的问题和未来的应用。我们还讨论了该测试结果对提高我们对大脑发病机制的理解以及对焦虑、前庭疾病、感觉运动解体及其应激诱导亚型的治疗的发展的意义。最后，我们提出了新的潜在途径，使这种行为范式适应啮齿动物临床前神经科学和药物发现研究的当前需求和挑战。

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The Suok ‘ropewalking’ test of rodent anxiety and sensorimotor disintegration: А 20-year summary of its application in neuroscience research

The Suok (ropewalking) test has been developed in 2004 to simultaneously assess rodent locomotor activity, anxiety-like behavior, sensorimotor disintegration, and their interplay. Over the last 20 years, this ‘hybrid’ test has been used in rat and mouse neurobehavioral research by various laboratories globally. Here, we provide a detailed overview of the Suok test, its past and present uses, methodological strengths, limitations, the existing problems, potential future modifications and practical applications. We also discuss the implications of results obtained in this test for improving our understanding of brain pathogenesis and the development of therapies for anxiety, vestibular disorders, sensorimotor disintegration and its stress-induced subtype. Finally, we suggest novel potential avenues for adapting this behavioral paradigm to the current needs and challenges of rodent preclinical neuroscience and drug discovery research.

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.