重述半乳糖凝集素-1、-3、-4和-9作为结直肠癌的生物靶点。

IF 2.4 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Cell Biology Pub Date : 2025-01-01 DOI:10.1139/bcb-2024-0218

Ammar Akram Kamarudin, Nadiah Abu

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引用次数: 0

摘要

半乳糖凝集素是一个高度保守的碳水化合物识别结构域，参与细胞的功能性活动，包括细胞生长、细胞增殖和粘附、信号转导等。据报道，凝集素在不同的组织类型中起着不同的作用，并与包括癌症在内的不同疾病有关。这些蛋白都有其特定的功能，关于半乳糖凝集素在结直肠癌中的作用的研究主要集中在半乳糖凝集素-1、-3、-4和-9。因此，这篇综述强调了某些凝集素在结直肠癌中的作用，以及它们在临床试验中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Revisiting galectin-1, -3, -4, and -9 as biotargets for colorectal cancer.

Galectins consist of a highly conserved carbohydrate recognition domain that involves in functional cellular activities including cell growth, cell proliferation and adhesion, signal transduction, and others. It has been reported that galectins play varying roles in distinct tissue types and have been implicated in different diseases, including cancer. Each of these proteins have its specific function and studies on the role of galectins in colorectal cancer mostly focusing on galectin-1, -3, -4, and -9. Thus, this review highlights the role of certain galectins in colorectal cancer, as well as their involvement in clinical trials.

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来源期刊

Biochemistry and Cell Biology 生物-生化与分子生物学

CiteScore

6.30

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Published since 1929, Biochemistry and Cell Biology explores every aspect of general biochemistry and includes up-to-date coverage of experimental research into cellular and molecular biology in eukaryotes, as well as review articles on topics of current interest and notes contributed by recognized international experts. Special issues each year are dedicated to expanding new areas of research in biochemistry and cell biology.