从无序到有序：低温电镜显示尼帕病毒聚合酶的rna依赖性重构。

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2025-05-30 DOI:10.1016/j.tibs.2025.05.003

Rupesh Balaji Jayachandran, Max Renner

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引用次数: 0

摘要

最近的一系列结构研究集中在致命人畜共患病原体尼帕病毒（NiV）的聚合酶复合体上。其中包括Sala等人描述RNA双结合状态的报告。这种结构构成了RNA合成周期早期延伸步骤的复合体快照。

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From disorder to order: cryo-EM reveals RNA-dependent remodeling of Nipah virus polymerase.

A flurry of recent structural studies have focused on the polymerase complex of the deadly zoonotic pathogen Nipah virus (NiV). These include a report by Sala et al. describing an RNA duplex-bound state. This structure constitutes a snapshot of the complex in an early elongation step of the RNA synthesis cycle.

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.