含四氢呋喃的药物：靶点、药理活性及其SAR研究。

IF 3.6 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2025-06-04 DOI:10.1002/cmdc.202500259

Yiou Mei, Yunfei Du

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引用次数: 0

摘要

四氢呋喃（THF）是一种碳氧环结构的五元环醚，是有机合成领域中常用的溶剂和重要的官能团。此外，THF在药物发现中也起着重要作用。美国食品和药物管理局（FDA）已经批准了13种用于一系列临床疾病的药物，如Terazosin和Darunavir。这些药物在多个治疗领域表现出优越的药理作用。本文综述了fda批准的含有四氢呋喃核的药物，重点介绍了它们的药理活性和构效关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Tetrahydrofuran-containing Pharmaceuticals: Targets, Pharmacological Activities, and Their SAR Studies.

Tetrahydrofuran (THF), a five-membered cyclic ether with a carbon-oxygen ring structure, is a common solvent and an important functional group in the field of organic synthesis methodology. In addition, THF also plays an important role in drug discovery. The US Food and Drug Administration (FDA) has approved a total of 13 drugs for a range of clinical diseases， such as Terazosin and Darunavir. These drugs exhibit superior pharmacological effects in multiple therapeutic fields. This review offers an extensive overview of FDA-approved drugs containing the tetrahydrofuran nucleus, emphasizing their pharmacological activities and structure-activity relationships.

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.