氯己定与聚维酮碘：揭示导管相关感染预防的未知，一篇叙述性综述

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health Pub Date : 2025-06-02 DOI:10.1016/j.jiph.2025.102851

Bertrand Drugeon , Claire M. Rickard , Jessica A. Schults , Jérémy Guenezan , Olivier Mimoz

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引用次数: 0

摘要

与医疗保健相关的感染仍然是一个主要问题，血管通路装置大大增加了感染风险。有效的皮肤消毒对于预防导管相关性感染（CRIs）至关重要。这篇综述比较了葡萄糖酸氯己定（CHG）和聚维酮碘（PVI）的疗效和安全性，同时也解决了经常被忽视的因素，如产品可获得性、应用技术、抗菌素耐药性和环境影响。证据支持在70% %异丙醇中使用2% % CHG是减少cri的最有效策略，尽管PVI仍然是CHG不耐受患者或低资源环境下的一种选择。环境分析表明CHG比PVI具有更高的持久性和潜在的生态风险。尽管有广泛的指南，但推荐浓度、应用方法和目标人群存在显著差异。基于文献综合，我们建议在可行的情况下标准化2 % CHG-IPA的使用，为高危人群制定量身定制的建议，并将环境和经济因素纳入未来的感染预防策略。

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Chlorhexidine and povidone-iodine: Unmasking the unknown in catheter-related infection prevention, a narrative review

Healthcare-associated infections remain a major concern, with vascular access devices contributing substantially to infection risk. Effective skin disinfection is essential for preventing catheter-related infections (CRIs). This narrative review compares the efficacy and safety of chlorhexidine gluconate (CHG) and povidone-iodine (PVI), while also addressing often-underexamined factors such as product availability, application techniques, antimicrobial resistance and environmental impact. Evidence supports the use of 2 % CHG in 70 % isopropyl alcohol as the most effective strategy to reduce CRIs, although PVI remains an alternative in patients with CHG intolerance or in low-resource settings. Environmental analyses highlight the higher persistence and potential ecological risk of CHG compared with PVI. Despite widespread guidelines, significant discrepancies persist in recommended concentrations, application methods, and target populations. Based on literature synthesis, we propose standardising the use of 2 % CHG-IPA where feasible, developing tailored recommendations for high-risk groups, and incorporating environmental and economic considerations into future infection prevention strategies.

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来源期刊

Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES

CiteScore

13.10

自引率

1.50%

发文量

203

审稿时长

96 days

期刊介绍： The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.