血清和尿液中肠道微生物群多样性与尿酸

IF 5.7 2区医学 Q1 UROLOGY & NEPHROLOGY

Kidney International Reports Pub Date : 2025-06-01 DOI:10.1016/j.ekir.2025.03.040

Cecilie Ness , Dmitri Svistounov , Marit D. Solbu , Natalia Petrenya , Neoma Boardman , Kirsti Ytrehus , Trond G. Jenssen , Andrew Holmes , Stephen J. Simpson , Svetlana N. Zykova

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引用次数: 0

摘要

越来越多的证据表明肠道微生物群在调节血清尿酸（SUA）水平中的重要性。在这项研究中，我们旨在确定肠道微生物群多样性，饮食，SUA和肾脏中尿酸（FEUA）分数排泄之间的关系。方法对53例SUA正常或升高的成人进行横断面研究，估计肾小球滤过率（eGFR）为37 ~ 124 ml/min / 1.73 m2。采用16S核糖体RNA测序分析粪便微生物组组成；α多样性以Simpson、Shannon和丰富度指数表示。收集饮食数据，利用主成分分析确定饮食模式。采用未经调整的线性回归和性别、腰臀比（WHR）和eGFR调整的模型来研究肠道微生物多样性、饮食模式评分和SUA/FEUA之间的关系。结果经多重校正后，shannon指数与SUA呈负相关(β−36.4,95% CI[−66.2 ~−6.7],P = 0.017；调整后R2 = 0.62, P <；0.001)。性别（标准化β = 0.52）和WHR（标准化β = 0.35）对SUA的影响最大，Shannon多样性指数（标准化β = - 0.22）次之。我们发现Shannon指数(标准化β = 0.49, P <；0.001)与调整性别和“甜”饮食模式后的FEUA呈正相关。该模型解释了FEUA中40%的变异(P <；0.001)。没有一种饮食模式与SUA或FEUA相关。结论较高的肠道微生物多样性与较低的SUA和肾脏更有效地消除尿酸有关。有必要研究评估干预肠道微生物组治疗高尿酸血症的有效性和安全性。

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Gut Microbiome Diversity and Uric Acid in Serum and Urine

Introduction

An increasing body of evidence has shown the importance of the gut microbiota in modulating serum uric acid (SUA) levels. In this study, we aimed to determine the association between gut microbiome diversity, diet, SUA, and fractional excretion of uric acid (FEUA) in the kidney.

Methods

A cross-sectional study was conducted in 53 adults with normal or elevated SUA and estimated glomerular filtration rate (eGFR) range from 37 to 124 ml/min per 1.73 m². Fecal microbiome composition was analyzed using 16S ribosomal RNA sequencing; and alpha diversity was expressed as reverse Simpson, Shannon, and Richness indices. Dietary data were collected, and dietary patterns were identified using principal component analysis. Unadjusted linear regression and models adjusted for sex, waist-hip ratio (WHR), and eGFR were used to study the association between gut microbial diversity, dietary pattern scores, and SUA/FEUA.

Results

Shannon index was negatively associated with SUA after multiple adjustment (β −36.4, 95% CI [−66.2 to −6.7], P = 0.017; adjusted R² = 0.62, P < 0.001). Sex (standardized β = 0.52) and WHR (standardized β = 0.35) had the highest effect on SUA, followed by Shannon diversity index (standardized β = −0.22). We found that Shannon index (standardized β = 0.49, P < 0.001) was positively associated with FEUA after adjustment for sex and “sweet” dietary pattern. This model explained 40% of the variability in FEUA (P < 0.001). None of the dietary patterns were associated with SUA or FEUA.

Conclusion

A higher gut microbial diversity was associated with lower SUA and more efficient elimination of uric acid by the kidneys. There is a need for studies assessing efficacy and safety of interventions on the gut microbiome as a treatment of hyperuricemia.

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来源期刊

Kidney International Reports Medicine-Nephrology

CiteScore

7.70

自引率

3.30%

发文量

1578

审稿时长

8 weeks

期刊介绍： Kidney International Reports, an official journal of the International Society of Nephrology, is a peer-reviewed, open access journal devoted to the publication of leading research and developments related to kidney disease. With the primary aim of contributing to improved care of patients with kidney disease, the journal will publish original clinical and select translational articles and educational content related to the pathogenesis, evaluation and management of acute and chronic kidney disease, end stage renal disease (including transplantation), acid-base, fluid and electrolyte disturbances and hypertension. Of particular interest are submissions related to clinical trials, epidemiology, systematic reviews (including meta-analyses) and outcomes research. The journal will also provide a platform for wider dissemination of national and regional guidelines as well as consensus meeting reports.