Giovanna Mafra e Silva , Geovanna Maria Malachias-Pires , Pablo Andre Brito de Souza , Ana Cássia Silva Oliveira , Jessica Vanina Ortiz , Bruna Kempfer Bossoli , Felipe Augusto Cerni , Luis Enrique Bermejo Galan , Roberto Carlos Cruz Carbonell , Manuela Berto Pucca
{"title":"下肢孤立性纤维性肿瘤:罕见病例报告,强调长期监测的重要性","authors":"Giovanna Mafra e Silva , Geovanna Maria Malachias-Pires , Pablo Andre Brito de Souza , Ana Cássia Silva Oliveira , Jessica Vanina Ortiz , Bruna Kempfer Bossoli , Felipe Augusto Cerni , Luis Enrique Bermejo Galan , Roberto Carlos Cruz Carbonell , Manuela Berto Pucca","doi":"10.1016/j.hmedic.2025.100270","DOIUrl":null,"url":null,"abstract":"<div><div>Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm of fibroblastic differentiation, characterized by unpredictable biological behavior. Although initially described in the pleura, it may occur in extrapleural sites, including soft tissues of the limbs, although this is uncommon. The definitive diagnosis relies on histopathological analysis combined with immunohistochemical markers such as CD34 and STAT6, the latter being highly sensitive and specific for SFT. While SFT often exhibits an indolent course, approximately 10–30 % of cases may develop local recurrences or metastases, reinforcing the importance of prognostic risk stratification and long-term follow-up after surgical resection.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100270"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Solitary fibrous tumor in the lower limb: A rare case report emphasizing the importance of long-term surveillance\",\"authors\":\"Giovanna Mafra e Silva , Geovanna Maria Malachias-Pires , Pablo Andre Brito de Souza , Ana Cássia Silva Oliveira , Jessica Vanina Ortiz , Bruna Kempfer Bossoli , Felipe Augusto Cerni , Luis Enrique Bermejo Galan , Roberto Carlos Cruz Carbonell , Manuela Berto Pucca\",\"doi\":\"10.1016/j.hmedic.2025.100270\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm of fibroblastic differentiation, characterized by unpredictable biological behavior. Although initially described in the pleura, it may occur in extrapleural sites, including soft tissues of the limbs, although this is uncommon. The definitive diagnosis relies on histopathological analysis combined with immunohistochemical markers such as CD34 and STAT6, the latter being highly sensitive and specific for SFT. While SFT often exhibits an indolent course, approximately 10–30 % of cases may develop local recurrences or metastases, reinforcing the importance of prognostic risk stratification and long-term follow-up after surgical resection.</div></div>\",\"PeriodicalId\":100908,\"journal\":{\"name\":\"Medical Reports\",\"volume\":\"13 \",\"pages\":\"Article 100270\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2949918625001159\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2949918625001159","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Solitary fibrous tumor in the lower limb: A rare case report emphasizing the importance of long-term surveillance
Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm of fibroblastic differentiation, characterized by unpredictable biological behavior. Although initially described in the pleura, it may occur in extrapleural sites, including soft tissues of the limbs, although this is uncommon. The definitive diagnosis relies on histopathological analysis combined with immunohistochemical markers such as CD34 and STAT6, the latter being highly sensitive and specific for SFT. While SFT often exhibits an indolent course, approximately 10–30 % of cases may develop local recurrences or metastases, reinforcing the importance of prognostic risk stratification and long-term follow-up after surgical resection.