The role of the oral microbiota in allergic diseases: Current understandings and future trends

Allergic diseases, including allergic asthma, allergic rhinitis, atopic dermatitis, and food allergy, have become a growing global health concern and impose significant public health burdens. The oral microbiota, integral to the oral ecosystem, has emerged as a crucial factor associated with the pathogenesis and progression of various diseases, including allergic diseases. Studies have revealed significant distinctions in the oral microbial community structure between allergic patients and healthy counterparts, suggesting the potential pivotal role of the oral microbiota in the onset and development of allergic diseases. This review summarized the implications and the underlying mechanisms of the oral microbiota in allergic diseases, providing novel insights and potential therapeutic targets for the prevention and treatment of allergic diseases.