金催化的Conia-Ene环化/Aza-Michael加成级联：获得具有抗癌活性的吲哚基lazepinone PNPs

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-05-23 DOI:10.1021/acs.joc.5c0062510.1021/acs.joc.5c00625

Xu Ling, Jinjie Wang, Yao Chen, Peirui Zhao, Dan Ni, Yue Wei, Shenyou Nie* and Yi He*,

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引用次数: 0

摘要

通过ugi金催化的Conia-ene环化/aza-Michael加成级联，建立了多种吲哚基lazepinone伪天然产物（PNPs）的模块化和流线型组装。机理研究表明，阳离子金作为一种独特的软路易斯酸，通过双重活化来完成这一过程。这种方法促进了化学和区域选择性地以中等到良好的产量获得目标PNPs，并具有显著的抗癌活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Gold-Catalyzed Conia-Ene Cyclization/Aza-Michael Addition Cascades: Access to Indolinylazepinone PNPs with Anticancer Activity

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Gold-Catalyzed Conia-Ene Cyclization/Aza-Michael Addition Cascades: Access to Indolinylazepinone PNPs with Anticancer Activity

A modular and streamlined assembly of diverse indolinylazepinone pseudonatural products (PNPs) has been established through post-Ugi gold-catalyzed Conia-ene cyclization/aza-Michael addition cascades. Mechanistic studies revealed that cationic gold acts as a unique soft Lewis acid to furnish this protocol through double activation. This approach facilitates chemo- and regioselective access to target PNPs in moderate to good yields with remarkable anticancer activity.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.