按需小胶质细胞提供治疗阿尔茨海默病的有效载荷

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-06-05 DOI:10.1016/j.stem.2025.05.003

Jessica M. Thanos, John R. Lukens

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引用次数: 0

摘要

在这期杂志中，Chadarevian等人发现，在阿尔茨海默病（AD）小鼠模型中，植入人类ipsc衍生的小胶质细胞（iMG），在斑块反应性CD9启动子下表达分泌性神经球蛋白（sNEP），可减少淀粉样蛋白负担、神经元损伤和炎症这些发现建立了一种基于细胞的治疗神经系统疾病的策略。

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On-demand microglia deliver the therapeutic payload in Alzheimer’s disease

In this issue, Chadarevian et al. showed that engraftment of human iPSC-derived microglia (iMG) engineered to express secreted neprilysin (sNEP) under the plaque-responsive CD9 promoter reduces amyloid burden, neuronal damage, and inflammation in an Alzheimer’s disease (AD) mouse model.¹ These findings establish a cell-based strategy to treat neurological diseases.

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.