Yixiang Lin, Haoling Xu, Jiayi Zheng, Tianxin Lin, Minhui Wang, Tingting Huang, Fabin Lin, Qinyong Ye, Guoen Cai
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引用次数: 0
摘要
功能性胃肠疾病（fgid）对帕金森病（PD）发病的影响尚不清楚。因此，在本研究中，我们研究了fgid及其亚型对PD发病的影响。在Cox比例风险模型中，fgid显著增加PD发病风险[风险比(HR) = 1.74, 95%可信区间(CI) = 1.30-2.33]。功能性消化不良（HR = 1.71, 95% CI = 1.17-2.52）和其他功能性肠道疾病（其他FIDs） （HR = 1.67, 95% CI = 1.00-2.78）也观察到类似的结果。中介分析显示，心理健康评分介导了fgid与功能性消化不良和PD发展之间10.00%和8.32%的关联。这项队列研究发现，fgid增加了患PD的风险。在功能性消化不良和其他FIDs以及心理健康介质中也可以观察到类似的作用，这是FIDs和功能性消化不良对PD的部分影响。
Association between functional gastrointestinal disorders and Parkinson’s disease in a prospective cohort study
The influence of functional gastrointestinal disorders (FGIDs) on the onset of Parkinson’s disease (PD) remains unclear. Therefore, in this study, we examined the effect of FGIDs and their subtypes on the PD onset. In Cox proportional hazards model, FGIDs significantly increased the risk of PD incidence [hazard ratio (HR) = 1.74, 95% confidence interval (CI) = 1.30–2.33]. Similar results were also observed for functional dyspepsia (HR = 1.71, 95% CI = 1.17–2.52) and other functional intestinal disorders (other FIDs) (HR = 1.67, 95% CI = 1.00–2.78). Mediation analyses revealed that mental health scores mediated 10.00% and 8.32% of the association between FGIDs and functional dyspepsia and PD development. This cohort study discovered that FGIDs increase the risk of developing PD. Similar effects can also be observed in functional dyspepsia and other FIDs and mental health mediates part of the effect of FGIDs and functional dyspepsia on PD.
期刊介绍：
npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.
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