新的诊断和分期框架应用于已建立的PD在BioFIND队列

IF 8.2 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2025-06-04 DOI:10.1038/s41531-025-00992-3

Marco J. Russo, Un Jung Kang

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引用次数: 0

摘要

提出的神经元α-突触核蛋白疾病综合分期系统（NSD-ISS）最近被应用于早期帕金森病（PD）队列。我们将这一研究框架应用于BioFIND研究队列，其中包括临床确诊的中度晚期PD患者。每个ISS阶段的疾病持续时间变化很大。认知和非运动锚点在确定分期方面的权重很小。分析强调了NSD-ISS的优势和局限性，以指导进一步完善综合分期系统。

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New diagnostic and staging framework applied to established PD in the BioFIND cohort

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New diagnostic and staging framework applied to established PD in the BioFIND cohort

The proposed Neuronal α-Synuclein Disease Integrated Staging System (NSD-ISS) was recently applied to early Parkinson’s disease (PD) cohorts. We applied this research framework to the BioFIND study cohort, which includes more moderately advanced PD participants with clinically established PD. Disease durations within each ISS stage were highly variable. Cognitive and non-motor anchors had little weight in determining staging. The analysis highlights strengths and limitations of NSD-ISS to guide further refinement of an integrated staging system.

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.