{"title":"冠状动脉周围脂肪组织衰减对经皮冠状动脉介入治疗后临床结果的影响。","authors":"Shota Naniwa, Hiroyuki Kawamori, Takayoshi Toba, Takashi Hiromasa, Yoichiro Sugizaki, Satoru Sasaki, Hiroyuki Fujii, Tomoyo Hamana, Yuto Osumi, Tetsuya Yamamoto, Seigo Iwane, Yuki Sakamoto, Koshi Matsuhama, Yuta Fukuishi, Hiroshi Tsunamoto, Kotaro Higuchi, Hiroya Okamoto, Masamichi Iwasaki, Tomofumi Takaya, Shinichiro Yamada, Ken-Ichi Hirata, Hiromasa Otake","doi":"10.4244/EIJ-D-24-00971","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Pericoronary adipose tissue (PCAT) attenuation, measured using coronary computed tomography angiography (cCTA), is a potential marker of coronary inflammation.</p><p><strong>Aims: </strong>We aimed to examine the association between coronary inflammation, as assessed by measuring PCAT attenuation before percutaneous coronary intervention (PCI), and clinical outcomes of PCI using current-generation drug-eluting stents (DES).</p><p><strong>Methods: </strong>We retrospectively studied consecutive patients who underwent cCTA before PCI with current-generation DES. Adverse plaque characteristics, calcified plaque (CP) burden, and PCAT attenuation of the proximal right coronary artery (PCAT<sub>RCA</sub>) were assessed using cCTA. The primary outcome was a patient-oriented composite endpoint (PoCE), including cardiovascular death, non-fatal myocardial infarction, any revascularisation, and stroke.</p><p><strong>Results: </strong>During a median follow-up of 1,540 days, 77 of 490 patients experienced PoCE. Patients with PoCE had higher PCAT<sub>RCA</sub> (-76.3±6.4 Hounsfield units [HU] vs -82.5±8.1 HU; p<0.001). Multivariable analysis showed that the presence of adverse plaque, greater CP burden and higher PCAT<sub>RCA</sub> were independently associated with PoCE (hazard ratio [HR] 2.05, 95% confidence interval [CI]: 1.26-3.34; p=0.004; HR 1.04, 95% CI: 1.02-1.07; p=0.002; and HR 2.20, 95% CI: 1.63-2.97; p<0.001, respectively). PoCE incidence was 3.9 times higher in patients with high PCAT<sub>RCA</sub> (≥-79.9 HU) than those with low PCAT<sub>RCA</sub> (.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"21 11","pages":"e605-e616"},"PeriodicalIF":9.5000,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138251/pdf/","citationCount":"0","resultStr":"{\"title\":\"Impact of pericoronary adipose tissue attenuation on clinical outcomes after percutaneous coronary intervention.\",\"authors\":\"Shota Naniwa, Hiroyuki Kawamori, Takayoshi Toba, Takashi Hiromasa, Yoichiro Sugizaki, Satoru Sasaki, Hiroyuki Fujii, Tomoyo Hamana, Yuto Osumi, Tetsuya Yamamoto, Seigo Iwane, Yuki Sakamoto, Koshi Matsuhama, Yuta Fukuishi, Hiroshi Tsunamoto, Kotaro Higuchi, Hiroya Okamoto, Masamichi Iwasaki, Tomofumi Takaya, Shinichiro Yamada, Ken-Ichi Hirata, Hiromasa Otake\",\"doi\":\"10.4244/EIJ-D-24-00971\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Pericoronary adipose tissue (PCAT) attenuation, measured using coronary computed tomography angiography (cCTA), is a potential marker of coronary inflammation.</p><p><strong>Aims: </strong>We aimed to examine the association between coronary inflammation, as assessed by measuring PCAT attenuation before percutaneous coronary intervention (PCI), and clinical outcomes of PCI using current-generation drug-eluting stents (DES).</p><p><strong>Methods: </strong>We retrospectively studied consecutive patients who underwent cCTA before PCI with current-generation DES. Adverse plaque characteristics, calcified plaque (CP) burden, and PCAT attenuation of the proximal right coronary artery (PCAT<sub>RCA</sub>) were assessed using cCTA. The primary outcome was a patient-oriented composite endpoint (PoCE), including cardiovascular death, non-fatal myocardial infarction, any revascularisation, and stroke.</p><p><strong>Results: </strong>During a median follow-up of 1,540 days, 77 of 490 patients experienced PoCE. Patients with PoCE had higher PCAT<sub>RCA</sub> (-76.3±6.4 Hounsfield units [HU] vs -82.5±8.1 HU; p<0.001). Multivariable analysis showed that the presence of adverse plaque, greater CP burden and higher PCAT<sub>RCA</sub> were independently associated with PoCE (hazard ratio [HR] 2.05, 95% confidence interval [CI]: 1.26-3.34; p=0.004; HR 1.04, 95% CI: 1.02-1.07; p=0.002; and HR 2.20, 95% CI: 1.63-2.97; p<0.001, respectively). PoCE incidence was 3.9 times higher in patients with high PCAT<sub>RCA</sub> (≥-79.9 HU) than those with low PCAT<sub>RCA</sub> (.</p>\",\"PeriodicalId\":54378,\"journal\":{\"name\":\"Eurointervention\",\"volume\":\"21 11\",\"pages\":\"e605-e616\"},\"PeriodicalIF\":9.5000,\"publicationDate\":\"2025-06-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138251/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Eurointervention\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4244/EIJ-D-24-00971\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eurointervention","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4244/EIJ-D-24-00971","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Impact of pericoronary adipose tissue attenuation on clinical outcomes after percutaneous coronary intervention.
Background: Pericoronary adipose tissue (PCAT) attenuation, measured using coronary computed tomography angiography (cCTA), is a potential marker of coronary inflammation.
Aims: We aimed to examine the association between coronary inflammation, as assessed by measuring PCAT attenuation before percutaneous coronary intervention (PCI), and clinical outcomes of PCI using current-generation drug-eluting stents (DES).
Methods: We retrospectively studied consecutive patients who underwent cCTA before PCI with current-generation DES. Adverse plaque characteristics, calcified plaque (CP) burden, and PCAT attenuation of the proximal right coronary artery (PCATRCA) were assessed using cCTA. The primary outcome was a patient-oriented composite endpoint (PoCE), including cardiovascular death, non-fatal myocardial infarction, any revascularisation, and stroke.
Results: During a median follow-up of 1,540 days, 77 of 490 patients experienced PoCE. Patients with PoCE had higher PCATRCA (-76.3±6.4 Hounsfield units [HU] vs -82.5±8.1 HU; p<0.001). Multivariable analysis showed that the presence of adverse plaque, greater CP burden and higher PCATRCA were independently associated with PoCE (hazard ratio [HR] 2.05, 95% confidence interval [CI]: 1.26-3.34; p=0.004; HR 1.04, 95% CI: 1.02-1.07; p=0.002; and HR 2.20, 95% CI: 1.63-2.97; p<0.001, respectively). PoCE incidence was 3.9 times higher in patients with high PCATRCA (≥-79.9 HU) than those with low PCATRCA (.
期刊介绍：
EuroIntervention Journal is an international, English language, peer-reviewed journal whose aim is to create a community of high quality research and education in the field of percutaneous and surgical cardiovascular interventions.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
