健康的马来西亚青春期前儿童的骨量、肌肉骨单位和骨转换标志物。

IF 2.8 Q3 ENDOCRINOLOGY & METABOLISM

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2025-06-04 DOI:10.6065/apem.2448232.116

Kanimolli Arasu, Winnie Chee Siew Swee, Connie M Weaver

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引用次数: 0

摘要

目的：需要亚洲健康儿童骨量、骨转换标志物（BTMs）和肌骨单位（MBU）的正常值，以便进行准确的骨骼评估。本横断面研究描述了243名马来西亚9至11岁的青春期前儿童的骨矿物质密度（BMD）、骨矿物质含量（BMC）、BTMs和MBU。方法：采用双能x线骨密度仪测定大鼠全身骨密度（TBBMD）、全身BMC （TBBMC）、腰椎骨密度（LSBMD）、腰椎BMC （LSBMC）及体成分。用BMC除以瘦体质量（LBM）计算总MBU和区域MBU。测定血清BTMs （CTX1、P1NP、BAP、OC）和血清iPTH。结果：在亚洲参考人群中，97.5%的参与者的TBBMD z -评分高于-1 SD， 2.5%的参与者有年龄低TBBMD的风险（-1.9至-1.0 SD），没有人有年龄低TBBMD(结论：本研究提供了一个基于人群的数据集，关于健康的马来西亚青春期前儿童的骨量，BTMs和MBU，能够准确评估该人群的骨骼。

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Bone mass, muscle bone unit and bone turnover markers in healthy preadolescent Malaysian children.

Purpose: Normative values of bone mass, bone turnover markers (BTMs) and muscle-bone unit (MBU) among healthy Asian children are needed to enable accurate skeletal assessment. This cross-sectional study characterises the bone mineral density (BMD), bone mineral content (BMC), BTMs and MBU of 243 Malaysian preadolescent children aged between 9 to 11 years.

Methods: Total body BMD (TBBMD), total body BMC (TBBMC), lumbar spine BMD (LSBMD), lumbar spine BMC (LSBMC) and body composition were assessed using dual-energy X-ray absorptiometry. Total and regional MBU was calculated by dividing BMC with lean body mass (LBM). Serum BTMs (CTX1, P1NP, BAP, OC) and serum iPTH were measured.

Results: Based on the Asian reference population, 97.5% of the participants had TBBMD Z-scores above -1 SD, 2.5% were at risk for low TBBMD for age (-1.9 to -1.0 SD) and no one had low TBBMD for age (<-2.0 SD). Participants had lower TBBMD than children of the same age from published data of Asian children despite having higher body weights. There were sex-specific differences in the BTMs and regional MBU of the participants.

Conclusion: This study provides a population-based dataset on bone mass, BTMs, and MBU of healthy preadolescent Malaysian children which enables accurate skeletal assessment in this population.

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来源期刊

Annals of Pediatric Endocrinology & Metabolism Multiple-

CiteScore

4.00

自引率

18.20%

发文量

审稿时长

24 weeks

期刊介绍： The Annals of Pediatric Endocrinology & Metabolism Journal is the official publication of the Korean Society of Pediatric Endocrinology. Its formal abbreviated title is “Ann Pediatr Endocrinol Metab”. It is a peer-reviewed open access journal of medicine published in English. The journal was launched in 1996 under the title of ‘Journal of Korean Society of Pediatric Endocrinology’ until 2011 (pISSN 1226-2242). Since 2012, the title is now changed to ‘Annals of Pediatric Endocrinology & Metabolism’. The Journal is published four times per year on the last day of March, June, September, and December. It is widely distributed for free to members of the Korean Society of Pediatric Endocrinology, medical schools, libraries, and academic institutions. The journal is indexed/tracked/covered by web sites of PubMed Central, PubMed, Emerging Sources Citation Index (ESCI), Scopus, EBSCO, EMBASE, KoreaMed, KoMCI, KCI, Science Central, DOI/CrossRef, Directory of Open Access Journals(DOAJ), and Google Scholar. The aims of Annals of Pediatric Endocrinology & Metabolism are to contribute to the advancements in the fields of pediatric endocrinology & metabolism through the scientific reviews and interchange of all of pediatric endocrinology and metabolism. It aims to reflect the latest clinical, translational, and basic research trends from worldwide valuable achievements. In addition, genome research, epidemiology, public education and clinical practice guidelines in each country are welcomed for publication. The Journal particularly focuses on research conducted with Asian-Pacific children whose genetic and environmental backgrounds are different from those of the Western. Area of specific interest include the following : Growth, puberty, glucose metabolism including diabetes mellitus, obesity, nutrition, disorders of sexual development, pituitary, thyroid, parathyroid, adrenal cortex, bone or other endocrine and metabolic disorders from infancy through adolescence.