即时尿自检测量替诺福韦依从性和预测病毒抑制的可行性。

IF 3.8 4区医学 Q2 IMMUNOLOGY

Open Forum Infectious Diseases Pub Date : 2025-05-17 eCollection Date: 2025-06-01 DOI:10.1093/ofid/ofaf300

Renata Buccheri, Matthew A Spinelli, Megan J Heise, David V Glidden, Kevin Sassaman, Tyler Martinson, Hannah R Schmidt, Alexa B D'Angelo, Dustin T Duncan, Keith J Horvath, Sabina Hirshfield, Renessa S Williams, Mallory O Johnson, Christian Grov, Adam Carrico, Monica Gandhi

{"title":"即时尿自检测量替诺福韦依从性和预测病毒抑制的可行性。","authors":"Renata Buccheri, Matthew A Spinelli, Megan J Heise, David V Glidden, Kevin Sassaman, Tyler Martinson, Hannah R Schmidt, Alexa B D'Angelo, Dustin T Duncan, Keith J Horvath, Sabina Hirshfield, Renessa S Williams, Mallory O Johnson, Christian Grov, Adam Carrico, Monica Gandhi","doi":"10.1093/ofid/ofaf300","DOIUrl":null,"url":null,"abstract":"This study is the first to demonstrate the feasibility of at-home adherence monitoring using a point-of-care urine assay for tenofovir (TFV). Undetectable TFV is strongly associated with lower viral suppression (odds ratio, 0.19, 95% CI, 0.10-0.34; P < .001), supporting a streamlined, effective approach for monitoring adherence between viral load assessments.","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 6","pages":"ofaf300"},"PeriodicalIF":3.8000,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131155/pdf/","citationCount":"0","resultStr":"{\"title\":\"Feasibility of Point-of-Care Urine Self-Testing to Measure Tenofovir Adherence and Predict Viral Suppression.\",\"authors\":\"Renata Buccheri, Matthew A Spinelli, Megan J Heise, David V Glidden, Kevin Sassaman, Tyler Martinson, Hannah R Schmidt, Alexa B D'Angelo, Dustin T Duncan, Keith J Horvath, Sabina Hirshfield, Renessa S Williams, Mallory O Johnson, Christian Grov, Adam Carrico, Monica Gandhi\",\"doi\":\"10.1093/ofid/ofaf300\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study is the first to demonstrate the feasibility of at-home adherence monitoring using a point-of-care urine assay for tenofovir (TFV). Undetectable TFV is strongly associated with lower viral suppression (odds ratio, 0.19, 95% CI, 0.10-0.34; P < .001), supporting a streamlined, effective approach for monitoring adherence between viral load assessments.\",\"PeriodicalId\":19517,\"journal\":{\"name\":\"Open Forum Infectious Diseases\",\"volume\":\"12 6\",\"pages\":\"ofaf300\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-05-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131155/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Open Forum Infectious Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/ofid/ofaf300\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Forum Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/ofid/ofaf300","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

这项研究首次证明了使用即时尿液检测替诺福韦（TFV）在家中进行依从性监测的可行性。无法检测到的TFV与较低的病毒抑制密切相关(优势比，0.19,95% CI, 0.10-0.34；P < .001)，支持一种简化、有效的方法来监测病毒载量评估之间的依从性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Feasibility of Point-of-Care Urine Self-Testing to Measure Tenofovir Adherence and Predict Viral Suppression.

This study is the first to demonstrate the feasibility of at-home adherence monitoring using a point-of-care urine assay for tenofovir (TFV). Undetectable TFV is strongly associated with lower viral suppression (odds ratio, 0.19, 95% CI, 0.10-0.34; P < .001), supporting a streamlined, effective approach for monitoring adherence between viral load assessments.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.